Prevalence of Helicobacter pylori Infection in Samples of Gastric Biopsies

Abstract

Background: Helicobacter pylori (H. pylori) infection affects about 50% of the world population and its association with environmental factors and host properties is involved in gastric carcinogenesis. The study aimed to estimate the prevalence ofH. pylori in samples of gastric mucosa biopsies, correlate the presence of the bacteria in the sample with the variables age, sex and origin, to identify the types of lesions found in patients withH. pylori, and to evaluate the association of the lesions with the region of the gastric mucosa.

Methods: A cross-sectional, retrospective study was carried out in Aracaju, Sergipe, Brazil, from January 2013 to December 2015. A total of 45,206 gastric mucosal biopsies were obtained from patients submitted to upper gastrointestinal endoscopy. Of the reports evaluated, 12,909 met the inclusion criteria since they presented the patients demographic data as well as the histopathological characteristics of gastric mucosal regions and positivity forH. pylori. Data were analyzed by IBM SPSS Statistic 20 and subjected to descriptive analyses (categorical variables) and inferential (Pearsons Qui-square and linear association tests) and multiple correspondence analyses. Significance level adopted 5%.

Results: Of the total of 12,909 (28.6%) reports evaluated, 67% (8,647) came from urban areas and 64.5% (8,320) were female. The mean age (standard deviation (SD)) was 43 years, ranging from 8 to 100 years, prevailing between 21 and 60 years. Among the types of gastric mucosa analyzed, 95.5% (12,322) were of the antral mucosa. The absence of glandular atrophy, the mild infection intensity forH. pylori, the absence of metaplasia, the presence of foveolar hyperplasia and lymphoid follicles were statistically significant (P < 0.001) in this region. In the fundic region, the evidence of fibrinoleucocytic crust and lymphoid follicles was significant (P < 0.001). There was no evidence of associated ulcerated lesions or significant relationship with intestinal metaplasia in the antral mucosa, whereas the fundic mucosa had a strong association with lymphoid follicles. The prevalence of active H. pylori infection in this study was 30.93%.

Conclusion: Detection rate ofH. pylori and its association with acute and chronic inflammation should be taken into account. The antral region has shown higher incidence and the presence ofH. pylori was strongly associated with foveolar hyperplasia and lymphoid follicles.




Gastroenterol Res. 2017;10(1):33-41
doi: https://doi.org/10.14740/gr785w