Hormonal Effects on Nodular GAVE

Alan Brijbassie, Abdullah Al Osaimi, Steven M Powell


Gastric antral vascular ectasia (GAVE) and its nodular antral gastropathy (NAG) variant is a unique lesion associated with hypergastrinemic hormonal alterations that may be compounded by concurrent proton pump inhibitor (PPI) therapy. The use of octreotide as a somatostatin analogue and its role in the down regulation of variousenteric hormones has been well documented however its use in the management of NAG has not been widely reported. We herein present a case where octreotide induced gastrin down-regulation as well as PPI cessation facilitated NAG resolution.

doi: http://dx.doi.org/10.4021/gr528w


Gastric antral vascular ectasia; Nodular antral gastropathy; Proton pump inhibitor

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