Adenosquamous Carcinoma of the Stomach: Report of Two Cases

Tadashi Terada


The author reports two cases of adenosquamous carcinoma of stomach. The first case is an 87-year-old woman who was admitted to our hospital because of nausea and vomiting. Endoscopy revealed a large type 4 tumor in the stomach, and biopsy showed squamous cell carcinoma. Total gastrectomy, cholecystectomy, splenectomy and lymph node dissection were performed. Pathologically, the gastric tumor consisted of a mixture of adenocarcinoma (30% in area) and squamous cell carcinoma (70% in areas). The adenocarcinoma consisted of signet ring cell carcinoma, poorly differentiated carcinoma, and tubular adenocarcinoma. Carcinoma cells invaded into the serosa. The gall bladder, lymph nodes and peritoneum showed metastases of adenocarcinoma. The patient died of five months after operation. The second case is a granulocyte-colony stimulating factor producing carcinoma. A 77-year-old woman was admitted to our hospital because of epigastralgia. Marked leukocytosis was present without inflammation. Endoscopic examination revealed a large type 3 tumor, and biopsy showed squamous cell carcinoma. Gastrectomy and lymph node dissection was performed. Pathologically the gastric tumor was composed of a mixture of adenocarcinoma (10%) and squamous cell carcinoma (90%). The carcinoma invaded into subserosa. Lymphovascular permeation is present. The adenocarcinoma element consisted of signet ring cell carcinoma. Tumor cells were immunohistochemically positive for granulocyte-colony stimulating factor. The lymph nodes showed metastases of signet ring cell carcinoma. The patient showed systemic metastasis, and died eight months after the operation.

Gastroenterol Res. 2009;2(1):54-56


Stomach; Adenosquamous carcinoma; Histopathology

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Gastroenterology Research, bimonthly, ISSN 1918-2805 (print), 1918-2813 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.

This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.