Biotherapy in the Adjuvant Treatment of Colorectal Cancer

El Mehdi Tazi, Ismail Essadi, Saber Boutayeb, Hind M’rabti, Hassan Errihani


The use of adjuvant chemotherapy has improved survival in early-stage colon cancer. Ongoing adjuvant clinical trials are evaluating the addition of targeted therapies to standard chemotherapy regimen. Preliminary results with bevacizumab were disappointing. Also, cetuximab added to chemotherapy does not seem to be better than chemotherapy alone, even in selected wild-type KRAS populations. A better understanding of mechanisms of action of drugs, tumor biology, and predictive biomarkers are needed to design future adjuvant trials.

Gastroenterol Res. 2011;4(4):162-167


Bevacizumab; Cetuximab; K-ras; FOLFOX; FOLFIRI

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