EGF-R Protein Expression and Gene Amplification do not Correlate in Pancreas Cancer

Gian Luca Baiocchi, Vincenzo Villanacci, Elisa Rossi, Daniela Zanotti, Stefano Maria Giulini


In a series of 13 pancreas cancer specimens, EGF-R was evaluated by means of both immunohistochemistry (IHC) for protein expression and FISH for genetic amplification. The results were discording in 7 cases (IHC positive, FISH negative), while in the remaining 6 cases both IHC and FISH were negative. The possible clinical implications of these results are discussed.

Gastroenterol Res. 2008;1(1):55-56


pancreas; cancer; EGF-R; FISH; immunoistochemistry

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