Mifepristone: An Uncommon Cause of Drug-Induced Liver Injury

Abstract

Mifepristone is frequently used in large doses for management of Cushings syndrome. This is a case of a 35-year-old woman with Cushings syndrome, who presented with abdominal pain and jaundice. A month prior to admission, she had been started on a daily dose of 1,200 mg mifepristone. After evaluating for various other causes of liver injury, biopsy revealed cholestatic pattern of liver disease, likely associated with drug-induced hepatotoxicity. Mifepristone was discontinued and her symptoms resolved. We believe this is one of the first few reported cases of drug-induced liver injury (DILI) associated with mifepristone use.




Gastroenterol Res. 2019;12(3):181-184
doi: https://doi.org/10.14740/gr1188