Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 10, Number 5, October 2017, pages 288-293

Proton Pump Inhibitor Use Is Associated With an Increased Frequency of Hospitalization in Patients With Cystic Fibrosis

Figure

Figure 1. Flowchart of initial screening for eligibility, exclusion and final number of patients included in analysis.

Tables

**Table 1.** Baseline Characteristics of Patients Hospitalized at Least Once in Year of Study and Non-Hospitalized Patients
	Not hospitalized in past year (n = 55)	Hospitalized at least once in past year (n = 59)	P value
^aPearson’s Chi-squared test (χ²). ^bMann-Whitney U test.
Male, % (n)	54.5% (30)	47.5% (28)	0.449^a
Age, median (range)	30 (24 - 41)	28 (24 - 35)	0.315^b
BMI, median (range)	22 (20.4 - 26.5)	20.2 (18.3 - 23.2)	0.003^b
Homozygous ΔF508, % (n)	39.6% (21)	61% (36)	0.024^a
ppFEV1, median (range)	69% (53 - 81)	40% (27 - 66)	< 0.001^b
Chronic pseudomonas colonization, % (n)	65.4% (36)	74.6% (44)	0.287^a
GER, % (n)	65.4% (36)	64.4% (38)	0.907^a
PPI use, % (n)	50.9% (28)	52.5% (31)	0.862^a
Pancreatic insufficiency, % (n)	78.2% (43)	83.1% (49)	0.510^a

**Table 2.** Baseline Characteristics of Proton Pump Inhibitor Users as Compared to Non-Users
	No daily PPI (n = 55)	Daily PPI (n = 59)	P value
^aPearson’s Chi-squared test (χ²). ^bMann-Whitney U test. ^cZero-inflated Poisson.
Male, % (n)	60% (33)	40% (25)	0.06^a
Age, median (range)	29 (24 - 38)	29 (24 - 34)	0.519^b
BMI, median (range)	20.72 (19.15 - 23.72)	21.35 (19.67 - 25.39)	0.155^b
F508 homozygous, % (n)	55.6 (30)	46.6 (27)	0.341^a
ppFEV₁, median (range)	57% (37 - 77)	57% (32 - 75)	0.932^b
Pseudomonas, % (n)	63.6% (35)	76.3% (45)	0.141^a
Number of hospitalizations, mean ± SD	0.9 ± 1.2	1.4 ± 2.1	0.009^c
GER, % (n)	30.9% (17)	96.6% (57)	< 0.001^b
Pancreatic insufficiency, % (n)	83.6% (46)	77.9% (46)	0.443^a

**Table 3.** Zero-Inflated Poisson Regression Predicting Hospitalization for Pulmonary Exacerbation Over Year of Study
Number of hospitalizations	IRR	Robust standard error	z	P value	95% confidence interval
PPI use	1.75	0.453	2.17	0.03	1.06	2.91
ppFEV₁	0.98	0.007	-2.84	0.005	0.97	0.99
BMI	1.01	0.024	0.32	0.751	0.96	1.06
Homozygous ΔF508	1.38	0.340	1.3	0.195	0.85	2.23
Chronic pseudomonas colonization	0.63	0.203	-1.44	0.149	0.33	1.18