Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 10, Number 4, August 2017, pages 213-217

Constipation Is Related to Small Bowel Disturbance Rather Than Colonic Enlargement in Acquired Chagasic Megacolon

**Table 1.** Clinical Groups and Demographic Data
Groups	Chagas disease	Barium enema	N	Constipation	Mean age (years)	Sex ratio (M/F)
ND: not done.
N	No	ND	9	No		47	3:6
CN	No	Normal	38	7 - 30	1 - 40	44	3:35
ChN	Yes	Normal	20	No		65	8:12
CCh	Yes	Normal	14	7 - 60	3 - 30	61	4:10
ChMc	Yes	Megacolon	16	No		64	7:9
CChMc	Yes	Megacolon	18	7 - 60	3 - 30	59	8:8

Table 1. Clinical Groups and Demographic Data

Groups

Chagas disease

Barium enema

Constipation

Mean age (years)

Sex ratio (M/F)

Days

Years

ND: not done.

3:6

Normal

7 - 30

1 - 40

3:35

ChN

Yes

Normal

8:12

CCh

Yes

Normal

7 - 60

3 - 30

4:10

ChMc

Yes

Megacolon

7:9

CChMc

Yes

Megacolon

7 - 60

3 - 30

8:8

**Table 2.** Results of Orocecal Transit Time in Clinical Groups
Groups	Subgroups	n	Mean (SD)	95% CI	OCTT (min)
SD: standard deviation; CI: confidence interval; OCTT: orocecal transit time. ^aP < 0.000; ^bP = 0.345; ^cP = 0.005; ^dP = 0.001 (Kruskal-Wallis test).
Non-constipated^a	N^b	9	87.0 (47.9)	52.8 - 121.2	8 (88.89)	1 (11.11)
	ChN^b	20	109.0 (54.6)	83.5 - 134.5	13 (65.0)	7 (35.0)
	ChMc^b	16	110.0 (63.8)	76.0 - 144.0	10 (66.67)	6 (33.33)
Constipated^a	CN^c	38	119.8 (55.4)	102.5 - 137.0	19 (50.0)	19 (50.0)
	CCh^c	14	93.3 (50.5)	65.4 - 121.3	5 (35.72)	9 (64.28)
	CChMc^c	18	172.6 (47.4)^d	149.8 - 195.5	1 (5.56)	17 (94.44)
Total		115	119.0 (58.8)	108.5 - 129.6	56	59

Table 2. Results of Orocecal Transit Time in Clinical Groups

Groups

Subgroups

Mean (SD)

95% CI

OCTT (min)

< 120, n (%)

> 120, n (%)

SD: standard deviation; CI: confidence interval; OCTT: orocecal transit time. ^aP < 0.000; ^bP = 0.345; ^cP = 0.005; ^dP = 0.001 (Kruskal-Wallis test).

Non-constipated^a

N^b

87.0 (47.9)

52.8 - 121.2

8 (88.89)

1 (11.11)

ChN^b

109.0 (54.6)

83.5 - 134.5

13 (65.0)

7 (35.0)

ChMc^b

110.0 (63.8)

76.0 - 144.0

10 (66.67)

6 (33.33)

Constipated^a

CN^c

119.8 (55.4)

102.5 - 137.0

19 (50.0)

CCh^c

93.3 (50.5)

65.4 - 121.3

5 (35.72)

9 (64.28)

CChMc^c

172.6 (47.4)^d

149.8 - 195.5

1 (5.56)

17 (94.44)

Total

115

119.0 (58.8)

108.5 - 129.6

**Table 3.** Oral Glucose Tolerance Test in Clinical Groups
Time (min)	Groups	n	Mean	SD	95% CI	P
Kruskal-Wallis test; min: minute. N and CN compared to ChMc, CCh, CChMc; N and CN compared to ChMc, CCh, CChMc; **N and CN compared to ChMc, CCh, CChMc and ChN compared to CChMc.
0	N	9	87.6	11.2	79.6	95.6	0.396
ChN	20	86.9	9.4	82.5	91.3
ChMc	16	87.7	8.9	82.9	92.4
CN	38	86.7	10.0	83.6	89.9
CCh	14	92.7	9.0	87.7	97.7
CChMc	18	88.6	9.4	84.1	93.2
30*	N	9	127.5	27.0	108.2	146.8	0.003
ChN	20	142.6	32.0	127.6	157.5
ChMc	16	155.5	39.8	134.3	176.7
CN	14	131.9	26.8	123.6	140.3
CCh	38	163.3	34.4	144.3	182.4
CChMc	18	157.2	29.9	142.8	171.6
60**	N	9	116.0	46.8	82.5	149.5	0.005
ChN	20	133.3	40.3	114.5	152.1
ChMc	16	152.4	49.2	126.2	178.6
CN	38	122.1	39.6	109.8	134.4
CCh	14	170.5	61.0	136.7	204.2
CChMc	18	145.2	37.3	127.2	163.2
90***	N	9	101.0	32.7	77.6	124.4	0.001
ChN	20	119.0	36.8	101.8	136.2
ChMc	16	135.7	48.0	110.1	161.3
CN	38	110.6	34.2	100.0	121.3
CCh	14	149.5	55.6	118.7	180.3
CChMc	18	144.2	37.7	126.0	162.4
120	N	9	92.9	24.3	75.5	110.3	0.400
ChN	20	102.5	30.8	88.1	116.9
ChMc	16	116.2	40.5	94.6	137.7
CN	14	98.3	28.0	89.5	107.0
CCh	38	122.3	55.6	91.5	153.1
CChMc	18	114.8	37.5	96.7	132.9

Table 3. Oral Glucose Tolerance Test in Clinical Groups

Time (min)

Groups

Mean

95% CI

Lower

Upper

Kruskal-Wallis test; min: minute. *N and CN compared to ChMc, CCh, CChMc; **N and CN compared to ChMc, CCh, CChMc; ***N and CN compared to ChMc, CCh, CChMc and ChN compared to CChMc.

87.6

11.2

79.6

95.6

0.396

ChN

86.9

9.4

82.5

91.3

ChMc

87.7

8.9

82.9

92.4

86.7

10.0

83.6

89.9

CCh

92.7

9.0

87.7

97.7

CChMc

88.6

9.4

84.1

93.2

30*

127.5

27.0

108.2

146.8

0.003

ChN

142.6

32.0

127.6

157.5

ChMc

155.5

39.8

134.3

176.7

131.9

26.8

123.6

140.3

CCh

163.3

34.4

144.3

182.4

CChMc

157.2

29.9

142.8

171.6

60**

116.0

46.8

82.5

149.5

0.005

ChN

133.3

40.3

114.5

152.1

ChMc

152.4

49.2

126.2

178.6

122.1

39.6

109.8

134.4

CCh

170.5

61.0

136.7

204.2

CChMc

145.2

37.3

127.2

163.2

90***

101.0

32.7

77.6

124.4

0.001

ChN

119.0

36.8

101.8

136.2

ChMc

135.7

48.0

110.1

161.3

110.6

34.2

100.0

121.3

CCh

149.5

55.6

118.7

180.3

CChMc

144.2

37.7

126.0

162.4

120

92.9

24.3

75.5

110.3

0.400

ChN

102.5

30.8

88.1

116.9

ChMc

116.2

40.5

94.6

137.7

98.3

28.0

89.5

107.0

CCh

122.3

55.6

91.5

153.1

CChMc

114.8

37.5

96.7

132.9