Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 10, Number 3, June 2017, pages 172-176


High C-Reactive Protein and Low Albumin Levels Predict High 30-Day Mortality in Patients Undergoing Percutaneous Endoscopic Gastrotomy

Figure

Figure 1.
Figure 1. Survival graph based on CRP and albumin.

Tables

Table 1. Characteristics of Patients Who Underwent PEG
 
CharacteristicsNumber (%)
Age
  < 6542 (35%)
  ≥ 6578 (65.0%)
Indication for PEG
  Cerebrovascular disease69 (57.5%)
  Neurologic disease25 (20.8%)
  Dementia16 (13.3%)
  Malignancy10 (8.3%)
Department conducting PEG
  Intensive care unit43 (35.8)
  Inpatient units77 (64.2%)

 

Table 2. Distribution of the Microbial Agents of Infections Developed After Percutaneous Endoscopic Gastrotomy
 
InfectionAgentNumber (%)
PEG site infection13 (10.3%)
Klebsiella spp.4 (30.7%)
Enterococcus faecium2 (15.3%)
Escherichia coli2 (15.3%)
Acinetobacter baumannii2 (15.3%)
Staphylococcus aureus1 (7.6%)
Proteus mirabilis1 (7.6%)
Stenotrophomonas maltophilia1 (7.6%)
Bloodstream infection6 (5.0%)
Candida albicans5 (83.3%)
Enterococcus faecium1 (16.7%)
Aspiration pneumonia3 (2.5%)
Klebsiella spp.3 (100%)

 

Table 3. Biomarker Levels and Comorbidities in Patients Based on 30-Day Mortality
 
Deceased (n = 34)Surviving (n = 86)P value
*Fisher’s exact test. **Chi-square test. ***Mann-Whitney U test.
Comorbid conditions
  Diabetes mellitus2 (5.9%)8 (9.3%)> 0.05*
  Coronary artery disease11 (32.4%)12 (14.0%)0.021**
  Cerebrovascular disease21 (61.8%)57 (66.3%)> 0.05**
  Dementia6 (17.6%)18 (20.9%)> 0.05**
  Malignancy-9 (10.5%)> 0.05*
  Hypertension11 (32.4%)27 (31.4%)> 0.05**
  Chronic kidney failure2 (5.9%)2 (2.3%)> 0.05*
Biomarkers
  CRP (mg/L)124.5 (19.2 - 737.0)28.6 (1.5 - 284.0)< 0.001***
  Albumin (g/dL)2.67 (0.3 - 4.2)2.97 (1.67 - 4.56)0.001***
  % neutrophil75.3 (38.8 - 96.5)83.3 (29.6 - 96.3)0.001***
  % lymphocyte14.5 (1.8 - 56.1)9.7 (2.9 - 29.1)0.001***
  Hemoglobin (g/dL)11.6 (7.3 - 18.2)9.9 (8.0 - 15.7)0.002***
 Platelet count (103/µL)286,150 (26,600 - 613,000)282,500 (23,250 -435,000)0.060***
  Leukocyte count (103/µL)9,258 (4,640 - 25,120)13,240 (1,536 -43,750)0.002***
  INR1.14 (0.85 - 1.54)1.09 (0.9 - 1.46)0.193***
  Creatinine (mg/dL)0.6 (0.1 - 4.1)0.6 (0.2 - 5.5)0.470***
Days of hospitalization prior to PEG13 (1 - 170)34 (2 - 89)< 0.001***

 

Table 4. Evaluation of Biomarkers Using ROC Analysis
 
Cut-off valueP valueSensitivity (%)Specificity (%)Positive predictive value (%)Negative predictive value (%)
CRP (mg/L)78.3< 0.00185.2 (82.8 - 87.3)74.5 (71.6 - 77.1)76.9 (74.9 - 78.8)83.4 (81.2 - 85.4)
Albumin (g/dL)2.710.00175.5 (72.7 - 78.1)61.8 (58.7 - 64.8)66.8 (64.4 - 68.3)71.6 (69.1 - 73.9
% neutrophil75.890.00182.3 (79.7 - 84.6)53.1 (49.9 - 56.2)63.7 (62.0 - 65.3)75 (72.1 -77.6)
% lymphocyte14.420.00151.8 (48.6 - 54.9)85.3 (82.9 - 87.4)77.8 (75.0 - 80.5)63.9 (62.2 - 65.4)
Hemoglobin (g/dL)9.940.00273.8 (70.9 - 76.5)58.9 (55.7 - 61.9)64.2 (62.3 - 66.1)69.2 (66.6 - 71.6)
Leukocyte count (103/µL)10,5300.00267.6 (63.9 - 69.8)66.7 (63.6 - 69.6)67.0 (64.8 - 69.1)66.4 (64.4 - 68.7)