Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 10, Number 3, June 2017, pages 166-171

Evaluation of Esophageal Functions by Manometry in Iron Deficiency Anemia Patients

**Table 1.** Clinical and Laboratory Features of Patients With IDA
Gender (F/M), n (%)	34/5 (87.2%/12.8%)
Mean age (years)	44.17 ± 2.27
Ferritin (ng/mL)	9.46 ± 6.75
MCV (µm³)	81.52 ± 6.42
Hb (g/L)	11.42 ± 0.86
Serum iron (µg/dL)	42.51 ± 20.80
Serum iron binding capacity (µg/dL)	402.97 ± 48.49
%Transferrin saturation	11.58 ± 5.81
Hb < 11 (g/L), n (%)	13 (33.3%)
Anemia duration (months)	34.37 ± 24.65
Dysphagia, n (%)	21 (53.8%)

Table 1. Clinical and Laboratory Features of Patients With IDA

Gender (F/M), n (%)

34/5 (87.2%/12.8%)

Mean age (years)

44.17 ± 2.27

Ferritin (ng/mL)

9.46 ± 6.75

MCV (µm³)

81.52 ± 6.42

Hb (g/L)

11.42 ± 0.86

Serum iron (µg/dL)

42.51 ± 20.80

Serum iron binding capacity (µg/dL)

402.97 ± 48.49

%Transferrin saturation

11.58 ± 5.81

Hb < 11 (g/L), n (%)

13 (33.3%)

Anemia duration (months)

34.37 ± 24.65

Dysphagia, n (%)

21 (53.8%)

**Table 2.** Manometric Findings in Patients With IDA Compared to Control Group
	IDA	Functional dyspepsia	P
LES resting pressure (mm Hg)	25.41 ± 11.67	19.96 ± 6.58	0.025
LES relaxation (%)	93.30 ± 9.88	95.53 ± 5.81	0.278
LES relaxation duration (s)	5.33 ± 1.61	8.75 ± 1.86	0.000
Esophagus contraction amplitude (mm Hg)	61.61 ± 24.21	63.23 ± 18.86	0.764
Peak velocity (cm/s)	12.67 ± 37.95	3.50 ± 1.63	0.191

Table 2. Manometric Findings in Patients With IDA Compared to Control Group

IDA

Functional dyspepsia

LES resting pressure (mm Hg)

25.41 ± 11.67

19.96 ± 6.58

0.025

LES relaxation (%)

93.30 ± 9.88

95.53 ± 5.81

0.278

LES relaxation duration (s)

5.33 ± 1.61

8.75 ± 1.86

0.000

Esophagus contraction amplitude (mm Hg)

61.61 ± 24.21

63.23 ± 18.86

0.764

Peak velocity (cm/s)

12.67 ± 37.95

3.50 ± 1.63

0.191

**Table 3.** Manometry Findings in Dysphagia Positive or Negative Patients Who Have IDA
	Dysphagia positive (n = 21)	Dysphagia negative (n = 18)	P
Mean age (years)	46.95 ± 16.42	40.94 ± 10.67	0.192
Anemia duration (months)	32.57 ± 26.69	36.90 ± 22.62	0.681
Motility impairment (n = 11), n (%)	8 (38.1%)	3 (16.7%)	0.130
LES resting pressure (mm Hg)	24.80 ± 11.53	26.11 ± 12.13	0.734
LES relaxation (%)	90.76 ± 12.79	96.27 ± 2.92	0.082
LES relaxation duration (s)	5.48 ± 1.91	5.15 ± 1.20	0.531
Esophagus contraction amplitude (mm Hg)	61.28 ± 23.39	62.00 ± 25.82	0.928
Peak velocity (cm/s)	20.54 ± 52.38	4.36 ± 1.36	0.199
Mean Hb (g/dL)	11.52 ± 0.95	11.29 ± 0.74	0.405
Mean ferritin (ng/mL)	8.90 ± 5.89	10.11 ± 7.76	0.585
MCV(µm³)	83.43 ± 5.10	79.30 ± 7.18	0.043
Serum iron (µg/dL)	46.19 ± 20.51	38.22 ± 20.89	0.238
% Transferrin saturation	11.28 ± 4.85	11.94 ± 6.88	0.729
Serum iron binding capacity (µg/dL)	412.09 ± 41.52	392.33 ± 54.82	0.209

Table 3. Manometry Findings in Dysphagia Positive or Negative Patients Who Have IDA

Dysphagia positive (n = 21)

Dysphagia negative (n = 18)

Mean age (years)

46.95 ± 16.42

40.94 ± 10.67

0.192

Anemia duration (months)

32.57 ± 26.69

36.90 ± 22.62

0.681

Motility impairment (n = 11), n (%)

8 (38.1%)

3 (16.7%)

0.130

LES resting pressure (mm Hg)

24.80 ± 11.53

26.11 ± 12.13

0.734

LES relaxation (%)

90.76 ± 12.79

96.27 ± 2.92

0.082

LES relaxation duration (s)

5.48 ± 1.91

5.15 ± 1.20

0.531

Esophagus contraction amplitude (mm Hg)

61.28 ± 23.39

62.00 ± 25.82

0.928

Peak velocity (cm/s)

20.54 ± 52.38

4.36 ± 1.36

0.199

Mean Hb (g/dL)

11.52 ± 0.95

11.29 ± 0.74

0.405

Mean ferritin (ng/mL)

8.90 ± 5.89

10.11 ± 7.76

0.585

MCV(µm³)

83.43 ± 5.10

79.30 ± 7.18

0.043

Serum iron (µg/dL)

46.19 ± 20.51

38.22 ± 20.89

0.238

% Transferrin saturation

11.28 ± 4.85

11.94 ± 6.88

0.729

Serum iron binding capacity (µg/dL)

412.09 ± 41.52

392.33 ± 54.82

0.209

**Table 4.** Manometry Findings in IDA Patients With Hemoglobin Levels Equal to or Above 11 and Hemoglobin Levels Below 11
	Hb ≤ 11 (n = 13)	Hb > 11 (n = 26)	P
Dysphagia (n = 21), n (%)	7 (53.8%)	14 (53.8%)	0.632
Anemia duration (months)	30.30 ± 24.99	37.28 ± 24.92	0.506
Motility impairment (n = 11), n (%)	5 (38.5%)	6 (23.1%)	0.262
LES resting pressure (mm Hg)	28.38 ± 14.18	23.92 ± 10.19	0.266
LES relaxation (%)	93.23 ± 8.61	93.34 ± 10.63	0.973
LES relaxation duration (s)	5.30 ± 1.40	5.35 ± 1.73	0.929
Esophagus contraction amplitude (mm Hg)	69.46 ± 28.88	57.69 ± 21.04	0.155
Peak velocity (cm/s)	3.83 ± 0.79	46.75 ± 9.54	0.304

Table 4. Manometry Findings in IDA Patients With Hemoglobin Levels Equal to or Above 11 and Hemoglobin Levels Below 11

Hb ≤ 11 (n = 13)

Hb > 11 (n = 26)

Dysphagia (n = 21), n (%)

7 (53.8%)

14 (53.8%)

0.632

Anemia duration (months)

30.30 ± 24.99

37.28 ± 24.92

0.506

Motility impairment (n = 11), n (%)

5 (38.5%)

6 (23.1%)

0.262

LES resting pressure (mm Hg)

28.38 ± 14.18

23.92 ± 10.19

0.266

LES relaxation (%)

93.23 ± 8.61

93.34 ± 10.63

0.973

LES relaxation duration (s)

5.30 ± 1.40

5.35 ± 1.73

0.929

Esophagus contraction amplitude (mm Hg)

69.46 ± 28.88

57.69 ± 21.04

0.155

Peak velocity (cm/s)

3.83 ± 0.79

46.75 ± 9.54

0.304