Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 10, Number 1, February 2017, pages 15-20

Symptomatic Diverticular Disease in Patients With Severely Reduced Kidney Function: Higher Rates of Complications and Transfusion Requirement

Figure 1. Forest plots showing the OR and 95% CI for the association of impaired renal function (GFR < 30 mL/min/1.73 m²) with abscess or perforation (a) and with transfusion requirement (b). The univariate OR, ORu, is provided, along with the adjusted OR (ORa) for each of the covariates indicated.

**Table 1.** Demographic and Baseline Characteristics of Patients With Symptomatic Diverticular Disease
	Normal to moderately reduced renal function	Severely reduced renal function	P-value
Age	63 ± 3.2 years	65 ± 3.5 years	0.61
Gender	Males: 124/214 (58%)	Males: 43/77 (56%)	0.47
Race
Black	51 (23.8%)	26 (33.8%)	0.39
White	141 (65.9%)	45 (58.4%)
Others	22 (10.3%)	6 (7.8%)
Comorbidities
Hypertension	27	33	0.40
Diabetes mellitus	18	24	0.38
CAD	11	12	0.18
CHF	14	15	0.40
COPD	27	25	0.35
Stroke	4	5	0.20
Cirrhosis	3	2	0.35
Medications
Immunosuppressive therapy	3	4	0.65
Anticoagulants	8	10	0.40

Table 1. Demographic and Baseline Characteristics of Patients With Symptomatic Diverticular Disease

Normal to moderately reduced renal function

Severely reduced renal function

P-value

Age

63 ± 3.2 years

65 ± 3.5 years

0.61

Gender

Males: 124/214 (58%)

Males: 43/77 (56%)

0.47

Race

Black

51 (23.8%)

26 (33.8%)

0.39

White

141 (65.9%)

45 (58.4%)

Others

22 (10.3%)

6 (7.8%)

Comorbidities

Hypertension

0.40

Diabetes mellitus

0.38

CAD

0.18

CHF

0.40

COPD

0.35

Stroke

0.20

Cirrhosis

0.35

Medications

Immunosuppressive therapy

0.65

Anticoagulants

0.40

**Table 2.** Characteristics of Patients with Complicated Diverticulitis
	GFR ≥ 30 mL/min/1.73 m²	GFR < 30 mL/min/1.73 m²	P-value
Age	55 ± 3 years	65 ± 4 years	0.24
Gender	Males: 20/31 (65%)	Males: 7/13 (54%)	0.59
Race
Black	5 (16%)	3 (23%)	0.95
White	23 (74%)	8 (62%)
Others	3 (10%)	2 (15%)
Total	31/136 (23%)	13/26 (50%)	Odds ratio: 3.4; 95% confidence interval: 1.423 - 8.06; P = 0.0073

Table 2. Characteristics of Patients with Complicated Diverticulitis

GFR ≥ 30 mL/min/1.73 m²

GFR < 30 mL/min/1.73 m²

P-value

Age

55 ± 3 years

65 ± 4 years

0.24

Gender

Males: 20/31 (65%)

Males: 7/13 (54%)

0.59

Race

Black

5 (16%)

3 (23%)

0.95

White

23 (74%)

8 (62%)

Others

3 (10%)

2 (15%)

Total

31/136 (23%)

13/26 (50%)

Odds ratio: 3.4; 95% confidence interval: 1.423 - 8.06; P = 0.0073

**Table 3.** Characteristics of Patients With Diverticular Bleeding With Transfusion
	GFR ≥ 30 mL/min/1.73 m²	GFR < 30 mL/min/1.73 m²	P-value
Age	71 ± 3.4 years	71 ± 2.4 years	0.26
Gender	Males: 8/11 (73%)	Males: 14/22 (64%)	0.23
Race
Black	3 (27%)	6 (27%)	0.25
White	6 (55%)	13 (59%)
Others	2 (18%)	3 (14%)
Total	31/136 (23%)	13/26 (50%)	Odds ratio: 4.6; 95% confidence interval: 1.99 - 10.76; P = 0.0004

Table 3. Characteristics of Patients With Diverticular Bleeding With Transfusion

GFR ≥ 30 mL/min/1.73 m²

GFR < 30 mL/min/1.73 m²

P-value

Age

71 ± 3.4 years

71 ± 2.4 years

0.26

Gender

Males: 8/11 (73%)

Males: 14/22 (64%)

0.23

Race

Black

3 (27%)

6 (27%)

0.25

White

6 (55%)

13 (59%)

Others

2 (18%)

3 (14%)

Total

31/136 (23%)

13/26 (50%)

Odds ratio: 4.6; 95% confidence interval: 1.99 - 10.76; P = 0.0004

**Table 4.** Length of Stay for the Different Study Groups
	GFR ≥ 30 mL/min/1.73 m²	GFR < 30 mL/min/1.73 m²	P-value
Uncomplicated diverticulitis	2.9 ± 1.9	5.8 ± 2.7	< 0.0001
Complicated diverticulitis (perforations/abscesses)	6.3 ± 4	8.5 ± 4.4	0.0001
Diverticular bleeding without transfusion requirement	3.1 ± 1.5	4.5 ± 3.6	0.03
Diverticular bleeding with transfusion requirement	8.5 ± 2.5	9 ± 5	0.04

Table 4. Length of Stay for the Different Study Groups

GFR ≥ 30 mL/min/1.73 m²

GFR < 30 mL/min/1.73 m²

P-value

Uncomplicated diverticulitis

2.9 ± 1.9

5.8 ± 2.7

< 0.0001

Complicated diverticulitis (perforations/abscesses)

6.3 ± 4

8.5 ± 4.4

0.0001

Diverticular bleeding without transfusion requirement

3.1 ± 1.5

4.5 ± 3.6

0.03

Diverticular bleeding with transfusion requirement

8.5 ± 2.5

9 ± 5

0.04