Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 7, Number 2, April 2014, pages 56-63

Liver Biopsy and FibroScan to Detect Early Histopathological Changes in Chronic HBV Patients Not Candidate for Treatment

**Table 1.** Description of Study Subjects in Relation to Age and Some Blood Parameters
	Mean	Std. deviation	Minimum	Maximum
Age	33.0	± 9.0	18.0	56.0
ALT	34.2	± 23.4	10.0	168.0
AST	31.0	± 15.7	8.0	124.0
Total bilirubin	0.9	± 1.5	0.3	17.0
Alpha-fetoprotein	4.2	± 3.4	0.3	23.0
S. albumin	5.8	± 0.49	2.0	5.2
Prothrombin	87.1	± 8.6	62.0	110.0
S. creatinine	0.88	± 0.23	0.4	2.1
Platelet	229.6	± 52.7	61.0	384.0
HBV DNA	8,262,839	± 36,755,837	52.0	308,000,000

Table 1. Description of Study Subjects in Relation to Age and Some Blood Parameters

Mean

Std. deviation

Minimum

Maximum

Age

33.0

± 9.0

18.0

56.0

ALT

34.2

± 23.4

10.0

168.0

AST

31.0

± 15.7

8.0

124.0

Total bilirubin

0.9

± 1.5

0.3

17.0

Alpha-fetoprotein

4.2

± 3.4

0.3

23.0

S. albumin

5.8

± 0.49

2.0

5.2

Prothrombin

87.1

± 8.6

62.0

110.0

S. creatinine

0.88

± 0.23

0.4

2.1

Platelet

229.6

± 52.7

61.0

384.0

HBV DNA

8,262,839

± 36,755,837

52.0

308,000,000

**Table 2.** Results of Abdominal Ultrasonography for Diagnosis of Liver Disease
Variable	Frequency	Percent
Abdominal ultrasound	Bright liver	38	28.1
Coarse	25	18.5
Hepatomegaly	40	29.6
Normal	32	23.7

Table 2. Results of Abdominal Ultrasonography for Diagnosis of Liver Disease

Variable

Frequency

Percent

Abdominal ultrasound

Bright liver

28.1

Coarse

18.5

Hepatomegaly

29.6

Normal

23.7

**Table 3.** Metavir Classification of Results of Liver Biopsy in the Study Patients Corresponding FibroScan Results Correlated With Metavir Scoring System
Variable	Number	Percent
*Cases that performed isolated liver biopsy were 33 cases (24.4%) while cases who performed isolated FibroScan were 76 case (56.3%). A third group of patients comprised of 26 patients performed both liver biopsy and FibroScan.
Liver biopsy*	F0	3	5.1
F1	36	61.0
F2	12	20.3
F3	8	13.6
FibroScan*	F0	48	47.1
F1	22	21.6
F2	27	26.5
F3	3	2.9
F4	2	2.0

Table 3. Metavir Classification of Results of Liver Biopsy in the Study Patients Corresponding FibroScan Results Correlated With Metavir Scoring System

Variable

Number

Percent

*Cases that performed isolated liver biopsy were 33 cases (24.4%) while cases who performed isolated FibroScan were 76 case (56.3%). A third group of patients comprised of 26 patients performed both liver biopsy and FibroScan.

Liver biopsy*

5.1

61.0

20.3

13.6

FibroScan*

47.1

21.6

26.5

2.9

2.0

**Table 4.** FibroScan As a Predictor for Liver Fibrosis
Variable	FibroScan	Mean	Std. deviation	P value
Age	Minimal fibrosis	32.7	8.3	0.005
Advanced fibrosis	39.7	9.4
ALT	Minimal fibrosis	27.1	9.5	< 0.001
Advanced fibrosis	49.3	24.4
AST	Minimal fibrosis	27.3	12.1	< 0.001
Advanced fibrosis	42.3	14.0
A fetoprotein	Minimal fibrosis	3.6	2.2	< 0.001
Advanced fibrosis	6.2	2.6
S. albumin	Minimal fibrosis	4.3	0.44	0.007
Advanced fibrosis	4.1	0.56
Prothrombin	Minimal fibrosis	90.5	6.5	< 0.001
Advanced fibrosis	79.1	8.2
S. creatinine	Minimal fibrosis	0.86	0.2	0.015
Advanced fibrosis	0.98	0.3
Total bilirubin	Minimal fibrosis	0.7	0.2	0.820
Advanced fibrosis	0.7	0.3
Platelets	Minimal fibrosis	240.3	42.8	0.053
Advanced fibrosis	216.6	45.6
HBV DNA/IUML	Minimal fibrosis	10,543,144	39,095,338	0.240
Advanced fibrosis	214,306	940,519

Table 4. FibroScan As a Predictor for Liver Fibrosis

Variable

FibroScan

Mean

Std. deviation

P value

Age

Minimal fibrosis

32.7

8.3

0.005

Advanced fibrosis

39.7

9.4

ALT

Minimal fibrosis

27.1

9.5

< 0.001

Advanced fibrosis

49.3

24.4

AST

Minimal fibrosis

27.3

12.1

< 0.001

Advanced fibrosis

42.3

14.0

A fetoprotein

Minimal fibrosis

3.6

2.2

< 0.001

Advanced fibrosis

6.2

2.6

S. albumin

Minimal fibrosis

4.3

0.44

0.007

Advanced fibrosis

4.1

0.56

Prothrombin

Minimal fibrosis

90.5

6.5

< 0.001

Advanced fibrosis

79.1

8.2

S. creatinine

Minimal fibrosis

0.86

0.2

0.015

Advanced fibrosis

0.98

0.3

Total bilirubin

Minimal fibrosis

0.7

0.2

0.820

Advanced fibrosis

0.7

0.3

Platelets

Minimal fibrosis

240.3

42.8

0.053

Advanced fibrosis

216.6

45.6

HBV DNA/IUML

Minimal fibrosis

10,543,144

39,095,338

0.240

Advanced fibrosis

214,306

940,519

**Table 5.** Liver Biopsy As a Predictor for the Degree of Liver Fibrosis
Variable	Liver biopsy	Mean	Std. deviation	P value
ALT	Minimal fibrosis	27.2	12.5	< 0.001
Advanced fibrosis	47.4	35.9
AST	Minimal fibrosis	26.4	9.1	< 0.001
Advanced fibrosis	37.6	21.9
S. albumin	Minimal fibrosis	4.3	0.47	0.002
Advanced fibrosis	3.9	0.39
Prothrombin	Minimal fibrosis	89.6	7.4	< 0.001
Advanced fibrosis	82.4	8.8

Table 5. Liver Biopsy As a Predictor for the Degree of Liver Fibrosis

Variable

Liver biopsy

Mean

Std. deviation

P value

ALT

Minimal fibrosis

27.2

12.5

< 0.001

Advanced fibrosis

47.4

35.9

AST

Minimal fibrosis

26.4

9.1

< 0.001

Advanced fibrosis

37.6

21.9

S. albumin

Minimal fibrosis

4.3

0.47

0.002

Advanced fibrosis

3.9

0.39

Prothrombin

Minimal fibrosis

89.6

7.4

< 0.001

Advanced fibrosis

82.4

8.8