Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 6, Number 3, June 2013, pages 95-102

Helicobacter Pylori Infection in a Group of Egyptian Children With Upper Gastro-Intestinal Bleeding

**Table 1.** Comparison Between Cases and Control Groups as Regards Demographic, Clinical and Laboratory Data
Item	Cases (no = 70)	Controls (no = 30)	P-value
significant, *highly significant.
Age (in years)
Range	4 - 14	4 - 13	0.122
Mean ± SD	6.4 ± 3.23	5.3 ± 2.9
Sex
Male	44 (62.9%)	18 (60%)	0.8
Female	26 (37.1%)	12 (40%)
Weight (centile)
Range		5 - 75	0.041*
Mean ± SD	27 ± 19.2	56.5 ± 20.2
Height (centile)
Range	3 - 75	3 - 50	0.320
Mean ± SD	25.2 ± 16.4	48.7 ± 15.5
BMI (centile)
Range	3 - 75	50 - 90	0.001**
Mean ± SD	29.2 ± 22.9	51 ± 3.1
Jaundice
Yes	18 (25.7%)	0 (0%)	0.001**
No	52 (74.3%)	30 (100%)
AST (U/L)
Range	20 - 400	14 - 33	0.01*
Mean ± SD	51.3 ± 58.2	23.1 ± 5.5
ALT (U/L)
Range	10 - 387	10 - 30	0.04*
Mean ± SD	49.6 ± 61.2	20.8 ± 5.8
Albumin (g/dL)
Range	3 - 5.5	3.8-5.2	0.143
Mean ± SD	4.2 ± 0.8	4.3 ± 0.5
P.C (%)
Range	50 - 100	70 - 100	0.003**
Mean ± SD	81.5 ± 17.7	91.9 ± 8
Total bilirubin (mg/dL)
Range	0.3 - 9.5	0.4 - 1	0.006**
Mean ± SD	1.9 ± 2.4	0.7 ± 0.1
Direct bilirubin (mg/dL)
Range	0.1 - 7.3	0.1 - 0.4	0.014*
Mean ± SD	0.9 ± 1.6	0.1 ± 0.09
Hemoglobin (g/dL)
Range	7 - 13	11 - 15	0.001**
Mean ± SD	10.6 ± 1.3	12.8 ± 1.03
Platelets (×10³/µL)
Range	190 - 500	168 - 500	0.290
Mean ± SD	339.5 ± 106.2	314.7 ± 107.6

Table 1. Comparison Between Cases and Control Groups as Regards Demographic, Clinical and Laboratory Data

Item

Cases (no = 70)

Controls (no = 30)

P-value

*significant, **highly significant.

Age (in years)

Range

4 - 14

4 - 13

0.122

Mean ± SD

6.4 ± 3.23

5.3 ± 2.9

Sex

Male

44 (62.9%)

18 (60%)

0.8

Female

26 (37.1%)

12 (40%)

Weight (centile)

Range

5 - 75

0.041*

Mean ± SD

27 ± 19.2

56.5 ± 20.2

Height (centile)

Range

3 - 75

3 - 50

0.320

Mean ± SD

25.2 ± 16.4

48.7 ± 15.5

BMI (centile)

Range

3 - 75

50 - 90

0.001**

Mean ± SD

29.2 ± 22.9

51 ± 3.1

Jaundice

Yes

18 (25.7%)

0 (0%)

0.001**

52 (74.3%)

30 (100%)

AST (U/L)

Range

20 - 400

14 - 33

0.01*

Mean ± SD

51.3 ± 58.2

23.1 ± 5.5

ALT (U/L)

Range

10 - 387

10 - 30

0.04*

Mean ± SD

49.6 ± 61.2

20.8 ± 5.8

Albumin (g/dL)

Range

3 - 5.5

3.8-5.2

0.143

Mean ± SD

4.2 ± 0.8

4.3 ± 0.5

P.C (%)

Range

50 - 100

70 - 100

0.003**

Mean ± SD

81.5 ± 17.7

91.9 ± 8

Total bilirubin (mg/dL)

Range

0.3 - 9.5

0.4 - 1

0.006**

Mean ± SD

1.9 ± 2.4

0.7 ± 0.1

Direct bilirubin (mg/dL)

Range

0.1 - 7.3

0.1 - 0.4

0.014*

Mean ± SD

0.9 ± 1.6

0.1 ± 0.09

Hemoglobin (g/dL)

Range

7 - 13

11 - 15

0.001**

Mean ± SD

10.6 ± 1.3

12.8 ± 1.03

Platelets (×10³/µL)

Range

190 - 500

168 - 500

0.290

Mean ± SD

339.5 ± 106.2

314.7 ± 107.6

**Table 2.** Comparison Between Variceal and Control Groups as Regards Demographic, Clinical and Laboratory Data
Item	Variceal (no = 18) ^§	Controls (no = 30)	P-value
§Variceal group includes: gastric varices (3 patients) and esophageal varices (15 patients), significant, *highly significant.
Age (in years)
Range	6 - 14	4 - 13	0.020*
Mean ± SD	8.6 ± 3.5	5.3 ± 2.9
Sex
Male	12 (66.7%)	18 (60%)	0.8
Female	6 (33.3%)	12 (40%)
Weight (centile)
Range	5 - 75	5 - 75	0.010*
Mean ± SD	21.7 ± 18.8	56.5 ± 20.2
Height (centile)
Range	3 - 50	5 - 90	0.130
Mean ± SD	22 ± 13.1	48.7 ± 15.5
BMI (centile)
Range	3 - 50	50 - 60	0.001**
Mean ± SD	21.7 ± 17.9	51 ± 3.1
Jaundice
Yes	14 (77.8%)	0 (0%)	0.006**
No	4 (22.2%)	30 (100%)
AST (U/L)
Range	34 - 400	14 - 33	0.001*
Mean ± SD	104.5 ± 92.2	23.1 ± 5.5
ALT (U/L)
Range	23 - 387	10 - 30	0.004*
Mean ± SD	111.3 ± 82.5	20.8 ± 5.8
Albumin (g/dL)
Range	3 - 4	3.8 - 5.2	0.01*
Mean ± SD	3.4 ± 0.3	4.3 ± 0.5
P.C (%)
Range	50 - 100	70 - 100	0.001**
Mean ± SD	64.4 ± 14	91.9 ± 8
Total bilirubin (mg/dL)
Range	0.8 - 9.5	0.4 - 1	0.001**
Mean ± SD	4.2 ± 2.7	0.7 ± 0.1
Direct bilirubin (mg/dL)
Range	0.1 - 7.3	0.1 - 0.4	0.001**
Mean ± SD	2.5 ± 2.1	0.1 ± 0.09
Hemoglobin (g/dL)
Range	7 - 11	11 - 15	0.01**
Mean ± SD	9.4 ± 0.8	12.8 ± 1.03
Platelets (×10³/µL)
Range	190 - 500	168 - 500	0.731
Mean ± SD	303 ± 117.7	314.7 ± 107.6

Table 2. Comparison Between Variceal and Control Groups as Regards Demographic, Clinical and Laboratory Data

Item

Variceal (no = 18) ^§

Controls (no = 30)

P-value

§Variceal group includes: gastric varices (3 patients) and esophageal varices (15 patients), *significant, **highly significant.

Age (in years)

Range

6 - 14

4 - 13

0.020*

Mean ± SD

8.6 ± 3.5

5.3 ± 2.9

Sex

Male

12 (66.7%)

18 (60%)

0.8

Female

6 (33.3%)

12 (40%)

Weight (centile)

Range

5 - 75

0.010*

Mean ± SD

21.7 ± 18.8

56.5 ± 20.2

Height (centile)

Range

3 - 50

5 - 90

0.130

Mean ± SD

22 ± 13.1

48.7 ± 15.5

BMI (centile)

Range

3 - 50

50 - 60

0.001**

Mean ± SD

21.7 ± 17.9

51 ± 3.1

Jaundice

Yes

14 (77.8%)

0 (0%)

0.006**

4 (22.2%)

30 (100%)

AST (U/L)

Range

34 - 400

14 - 33

0.001*

Mean ± SD

104.5 ± 92.2

23.1 ± 5.5

ALT (U/L)

Range

23 - 387

10 - 30

0.004*

Mean ± SD

111.3 ± 82.5

20.8 ± 5.8

Albumin (g/dL)

Range

3 - 4

3.8 - 5.2

0.01*

Mean ± SD

3.4 ± 0.3

4.3 ± 0.5

P.C (%)

Range

50 - 100

70 - 100

0.001**

Mean ± SD

64.4 ± 14

91.9 ± 8

Total bilirubin (mg/dL)

Range

0.8 - 9.5

0.4 - 1

0.001**

Mean ± SD

4.2 ± 2.7

0.7 ± 0.1

Direct bilirubin (mg/dL)

Range

0.1 - 7.3

0.1 - 0.4

0.001**

Mean ± SD

2.5 ± 2.1

0.1 ± 0.09

Hemoglobin (g/dL)

Range

7 - 11

11 - 15

0.01**

Mean ± SD

9.4 ± 0.8

12.8 ± 1.03

Platelets (×10³/µL)

Range

190 - 500

168 - 500

0.731

Mean ± SD

303 ± 117.7

314.7 ± 107.6

**Table 3.** Comparison Between Non-Variceal and Control Groups as Regards Demographic, Clinical and Laboratory Data
Item	Non-Variceal (no = 52) ^§	Controls (no = 30)	P-value
§Non-variceal group includes: gastritis (38 patients), duodenitis (9 patients), esophagitis (2 patients), multiple duodenal polyps (1 patient) and Mallory Weiss tear (2 patients), significant, *highly significant.
Age (in years)
Range	4 - 10	4 - 13	0.348
Mean ± SD	6.01 ± 3.3	5.3 ± 2.9
Sex
Male	32 (61.5%)	18 (60%)	0.9
Female	20 (38.5%)	12 (40%)
Weight (centile)
Range	3 - 75	5 - 75	0.01*
Mean ± SD	29.9 ± 17.5	56.5 ± 20.2
Height (centile)
Range	5 - 75	3 - 50	0.532
Mean ± SD	26.3 ± 17.4	28.7 ± 15.5
BMI (centile)
Range	3 - 75	50 - 90	0.001**
Mean ± SD	31.7 ± 24.07	51 ± 3.1
Jaundice
Yes	4 (7.7%)	0 (0%)	0.3
No	48 (92.3%)	30 (100%)
AST (U/L)
Range	20 - 79	14 - 33	0.09
Mean ± SD	37.1 ± 12.2	23.1 ± 5.5
ALT (U/L)
Range	10 - 55	10 - 30	0.08
Mean ± SD	24.7 ± 9.3	20.8 ± 5.8
Albumin (g/dL)
Range	3 - 5.5	3.8-5.2	0.803
Mean ± SD	4.4 ± 0.6	4.3 ± 0.5
P.C (%)
Range	50 - 100	70 - 100	0.122
Mean ± SD	87.3 ± 14.8	91.9 ± 8
Total bilirubin (mg/dL)
Range	0.3 - 0.8	0.4 - 1	0.179
Mean ± SD	1.5 ± 1.1	0.7 ± 0.1
Direct bilirubin (mg/dL)
Range	0.1 - 3.5	0.1 - 0.4	0.242
Mean ± SD	0.6 ± 0.3	0.1 ± 0.09
Hemoglobin (g/dL)
Range	8 - 13	11 - 15	0.001**
Mean ± SD	11.3 ± 1.01	12.8 ± 1.03
Platelets (×10³/µL)
Range	190 - 500	168 - 500	0.118
Mean ± SD	352.03 ± 100.1	314.7 ± 107.6

Table 3. Comparison Between Non-Variceal and Control Groups as Regards Demographic, Clinical and Laboratory Data

Item

Non-Variceal (no = 52) ^§

Controls (no = 30)

P-value

§Non-variceal group includes: gastritis (38 patients), duodenitis (9 patients), esophagitis (2 patients), multiple duodenal polyps (1 patient) and Mallory Weiss tear (2 patients), *significant, **highly significant.

Age (in years)

Range

4 - 10

4 - 13

0.348

Mean ± SD

6.01 ± 3.3

5.3 ± 2.9

Sex

Male

32 (61.5%)

18 (60%)

0.9

Female

20 (38.5%)

12 (40%)

Weight (centile)

Range

3 - 75

5 - 75

0.01*

Mean ± SD

29.9 ± 17.5

56.5 ± 20.2

Height (centile)

Range

5 - 75

3 - 50

0.532

Mean ± SD

26.3 ± 17.4

28.7 ± 15.5

BMI (centile)

Range

3 - 75

50 - 90

0.001**

Mean ± SD

31.7 ± 24.07

51 ± 3.1

Jaundice

Yes

4 (7.7%)

0 (0%)

0.3

48 (92.3%)

30 (100%)

AST (U/L)

Range

20 - 79

14 - 33

0.09

Mean ± SD

37.1 ± 12.2

23.1 ± 5.5

ALT (U/L)

Range

10 - 55

10 - 30

0.08

Mean ± SD

24.7 ± 9.3

20.8 ± 5.8

Albumin (g/dL)

Range

3 - 5.5

3.8-5.2

0.803

Mean ± SD

4.4 ± 0.6

4.3 ± 0.5

P.C (%)

Range

50 - 100

70 - 100

0.122

Mean ± SD

87.3 ± 14.8

91.9 ± 8

Total bilirubin (mg/dL)

Range

0.3 - 0.8

0.4 - 1

0.179

Mean ± SD

1.5 ± 1.1

0.7 ± 0.1

Direct bilirubin (mg/dL)

Range

0.1 - 3.5

0.1 - 0.4

0.242

Mean ± SD

0.6 ± 0.3

0.1 ± 0.09

Hemoglobin (g/dL)

Range

8 - 13

11 - 15

0.001**

Mean ± SD

11.3 ± 1.01

12.8 ± 1.03

Platelets (×10³/µL)

Range

190 - 500

168 - 500

0.118

Mean ± SD

352.03 ± 100.1

314.7 ± 107.6