Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 6, Number 1, February 2013, pages 17-25

Association Between Appendectomy and Fibrosis Progression in Nonalcoholic Fatty Liver Disease

**Table 1.** Histological Features of Patients With NAFLD and CHB
	NAFLD patientsn = 52	CHB patientsn = 68
Brunt fibrosis stage
0-1	28 (53.8%)
2	12 (23.1%)
3	8 (15.4%)
4	4 (7.7%)
Knodell fibrosis score
0		9 (13.2%)
1		26 (38.2%)
3		26 (38.2%)
4		7 (10.9%)
Mild fibrosis	40	35
Advanced fibrosis	12	33
Severity of Steatosis
0	0 (0%)	37 (54.4%)
1	17 (32.7%)	21 (30.9%)
2	23 (44.2%)	9 (13.2%)
3	12 (23.1%)	1 (1.5%)

Table 1. Histological Features of Patients With NAFLD and CHB

NAFLD patientsn = 52

CHB patientsn = 68

Brunt fibrosis stage

0-1

28 (53.8%)

12 (23.1%)

8 (15.4%)

4 (7.7%)

Knodell fibrosis score

9 (13.2%)

26 (38.2%)

7 (10.9%)

Mild fibrosis

Advanced fibrosis

Severity of Steatosis

0 (0%)

37 (54.4%)

17 (32.7%)

21 (30.9%)

23 (44.2%)

9 (13.2%)

12 (23.1%)

1 (1.5%)

**Table 2.** Clinical Features of NAFLD and CHB Patients, and Univariate Comparison of Clinical and Histological Features of Patients
	NAFLD patients	CHB patients	P value
Number	52	68
Age	48	39.5	0.102
Gender (Female)	21 (40.4%)	22 (32.4%)	0.365
BMI (kg/m²)	27.7	22.8	< 0.001
Obesity (BMI > 25)	39 (75.0%)	21 (30.9%)	< 0.001
Diabetes	24 (46.2%)	5 (7.4%)	< 0.001
Hyperlipidemia	35 (67.3%)	22 (32.4%)	< 0.001
Hypertension	32 (61.5%)	22 (32.4%)	0.002
AST (U/L)	63	49.5	0.319
ALT (U/L)	92.5	78.5	0.136
Total bilirubin (mg/dL)	0.6	0.7	0.134
Albumin (g/dL)	4.2	4	< 0.001
Triglycerides (mg/dL)	151	95	< 0.001
Total cholesterol (mg/dL)	207	177	< 0.001
Glucose (mg/dL)	101	89	< 0.001
Platelet count (10⁴/µL)	19.8	16.1	0.004
Prothrombin time (%)	100	95.5	0.115
Appendectomy	19 (36.5%)	12 (17.6%)	0.020
Steatosis (grade 0/1/2/3)	0/23/17/12	37/21/9/1	0.001

Table 2. Clinical Features of NAFLD and CHB Patients, and Univariate Comparison of Clinical and Histological Features of Patients

NAFLD patients

CHB patients

P value

Number

Age

39.5

0.102

Gender (Female)

21 (40.4%)

22 (32.4%)

0.365

BMI (kg/m²)

27.7

22.8

< 0.001

Obesity (BMI > 25)

39 (75.0%)

21 (30.9%)

< 0.001

Diabetes

24 (46.2%)

5 (7.4%)

< 0.001

Hyperlipidemia

35 (67.3%)

22 (32.4%)

< 0.001

Hypertension

32 (61.5%)

22 (32.4%)

0.002

AST (U/L)

49.5

0.319

ALT (U/L)

92.5

78.5

0.136

Total bilirubin (mg/dL)

0.6

0.7

0.134

Albumin (g/dL)

4.2

< 0.001

Triglycerides (mg/dL)

151

< 0.001

Total cholesterol (mg/dL)

207

177

< 0.001

Glucose (mg/dL)

101

< 0.001

Platelet count (10⁴/µL)

19.8

16.1

0.004

Prothrombin time (%)

100

95.5

0.115

Appendectomy

19 (36.5%)

12 (17.6%)

0.020

Steatosis (grade 0/1/2/3)

0/23/17/12

37/21/9/1

0.001

**Table 3.** Univariate Comparison of Clinical and Histological Features Between the Two Groups of NAFLD or CHB Patients Divided by Degree of Fibrosis
	NAFLD	CHB
Number	40	12		35	33
Age	40	59.0	0.002	37	41	0.390
Gender (Female)	12 (30.0%)	9 (75.0%)	0.006	11 (31.4%)	11 (33.3%)	0.868
BMI (kg/m²)	27.7	28.0	0.983	21.8	23.8	0.052
Obesity (BMI > 25)	29 (72.5%)	10 (83.3%)	0.452	8 (22.9%)	13 (39.4%)	0.143
Diabetes	16 (40.0%)	8 (66.7%)	0.108	2 (5.7)	3 (9.1%)	0.597
Hyperlipidemia	28 (70.0%)	7 (58.3%)	0.454	12 (34.3%)	10 (30.3%)	0.728
Hypertension	24 (60.0%)	8 (66.7%)	0.680	10 (28.6%)	12 (36.4%)	0.496
AST (U/L)	55	73.5	0.487	50	49	0.750
ALT (U/L)	93	81.5	0.307	76	79	0.589
Total bilirubin (mg/dL)	0.6	0.8	0.081	0.8	0.6	0.083
Albumin (g/dL)	4.3	4.0	0.016	4	3.7	0.160
Triglycerides (mg/dL)	156.5	128.0	0.400	82	105	0.393
Total cholesterol (mg/dL)	209	193	0.196	169	178	0.599
Glucose (mg/dL)	96	111	0.424	85	92	0.233
Platelet count (10⁴/µL)	22.8	14.2	< 0.001	18.5	15.2	0.004
Prothrombin time (%)	100	77.5	< 0.001	98.6	86	0.003
Appendectomy	11 (27.5%)	8 (66.7%)	0.014	6 (17.1%)	6 (18.2%)	0.911
Steatosis (grade 0/1/2/3)	0/11/17/12	0/6/6/0	0.036	21/7/6/1	16/14/3/0	0.717

Table 3. Univariate Comparison of Clinical and Histological Features Between the Two Groups of NAFLD or CHB Patients Divided by Degree of Fibrosis

NAFLD

CHB

Mild fibrosis

Advanced fibrosis

P value

Mild fibrosis

Advanced fibrosis

P value

Number

Age

59.0

0.002

0.390

Gender (Female)

12 (30.0%)

9 (75.0%)

0.006

11 (31.4%)

11 (33.3%)

0.868

BMI (kg/m²)

27.7

28.0

0.983

21.8

23.8

0.052

Obesity (BMI > 25)

29 (72.5%)

10 (83.3%)

0.452

8 (22.9%)

13 (39.4%)

0.143

Diabetes

16 (40.0%)

8 (66.7%)

0.108

2 (5.7)

3 (9.1%)

0.597

Hyperlipidemia

28 (70.0%)

7 (58.3%)

0.454

12 (34.3%)

10 (30.3%)

0.728

Hypertension

24 (60.0%)

8 (66.7%)

0.680

10 (28.6%)

12 (36.4%)

0.496

AST (U/L)

73.5

0.487

0.750

ALT (U/L)

81.5

0.307

0.589

Total bilirubin (mg/dL)

0.6

0.8

0.081

0.8

0.6

0.083

Albumin (g/dL)

4.3

4.0

0.016

3.7

0.160

Triglycerides (mg/dL)

156.5

128.0

0.400

105

0.393

Total cholesterol (mg/dL)

209

193

0.196

169

178

0.599

Glucose (mg/dL)

111

0.424

0.233

Platelet count (10⁴/µL)

22.8

14.2

< 0.001

18.5

15.2

0.004

Prothrombin time (%)

100

77.5

< 0.001

98.6

0.003

Appendectomy

11 (27.5%)

8 (66.7%)

0.014

6 (17.1%)

6 (18.2%)

0.911

Steatosis (grade 0/1/2/3)

0/11/17/12

0/6/6/0

0.036

21/7/6/1

16/14/3/0

0.717

**Table 4.** Multiple Logistic Regression Analysis of Factors Associated With Advanced Fibrosis in NAFLD Patients
	Odds ratio	95% CI	P value
Age	1.009	0.825 - 1.139	0.500
Gender(Female)	3.805	0.264 - 54.79	0.753
Albumin(g/dL)	0.120	0.001 - 14.45	0.460
Platelet count (10⁴/µL)	0.349	0.137 - 0.891	0.033
Appendectomy	39.415	1.109 - 1400.73	0.044
Steatosis	8.045	0.556 - 116.3	0.103

Table 4. Multiple Logistic Regression Analysis of Factors Associated With Advanced Fibrosis in NAFLD Patients

Odds ratio

95% CI

P value

Age

1.009

0.825 - 1.139

0.500

Gender(Female)

3.805

0.264 - 54.79

0.753

Albumin(g/dL)

0.120

0.001 - 14.45

0.460

Platelet count (10⁴/µL)

0.349

0.137 - 0.891

0.033

Appendectomy

39.415

1.109 - 1400.73

0.044

Steatosis

8.045

0.556 - 116.3

0.103