Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 4, Number 5, October 2011, pages 203-209

Predictability of Gastric Intestinal Metaplasia by Mottled Patchy Erythema Seen on Endoscopy

Figures

Figure 1.
Figure 1. Endoscopic finding of MPE. (A) Multiple and flat erythema in the antrum; (B) Flat and depressed erythema in the lesser curvature of the antrum.
Figure 2.
Figure 2. Biopsy site. (★) Biopsy site of MPE; (•) Biopsy site of non-MPE. Non-MPE site was defined as an adjacent mucosa located within 3 cm of MPE site.
Figure 3.
Figure 3. Evaluation for intestinal metaplasia using immunohistochemical staining (complete type case). (A) Hematoxylin and eosin stain; (B) MUC2 stain; (C) MUC5AC stain; (D) MUC6 stain; (E) CD10 stain; (F) CDX2 stain.

Tables

Table 1. Demographic Characteristics of Patients (n = 102)
 
MPE + (n = 55)MPE - (n = 47)P value
Mean age ± SD (years)66.1 (14.0)62.1 (14.4)0.080
Male sex33 (60.0%)22 (46.8%)0.183
Period after eradication ± SD (months)27.8 (23.8)23.4 (13.7)0.134
Endoscopic gastric atrophy (moderate to severe)36 (65.5%)21 (45%)0.035

 

Table 2. Comparison of IM Score Between MPE and Non-MPE Site (n = 55)
 
IM scoreMPE site (n = 55)Non-MPE site (n = 55)P value
07 (13%)37 (67%)
115 (27%)9 (16%)
216 (29%)5 (9%)
317 (31%)4 (7%)< 0.001

 

Table 3. Phenotypes and Subtypes of Intestinal Metaplasia
 
MPE site (n = 48)Non-MPE site (n = 18)P value
Phenotypes
  MUC2 positive48 (100%)18 (100%)
  MUC5AC positive28 (58.3%)9 (50.0%)0.587
  MUC6 positive11 (22.9%)6 (33.3%)0.528
  CD10 positive36 (75.0%)14 (77.8%)1.000
  CDX2 positive41 (85.4%)15 (83.3%)1.000
Subtypes
  Incomplete/Complete18/308/100.778