Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 4, Number 6, December 2011, pages 262-267


Helicobacter Pylori DNA in Liver Tissues From Chronic Hepatitis C Egyptian Patients

Figure

Figure 1.
Figure 1. Amplification of a 480-bp 16S rRNA DNA fragment of Helicobacter. Lane M: molecular size marker (100 - 1000 bp); lane 2, 4, 5: positive samples; lane 6: negative control (double-distilled water).

Tables

Table 1. Characteristics of the Chronic Hepatitis C Patients
 
VariablesN = 52
*mean ± SD; # median (range); number (%).
Age (year)*42.5 ± 7.4
Gender
  Males39 (75)
  Females13 (25)
ALT (IU/L)*56.8 ± 32.5
AST (IU/L)*50.7 ± 24.7
Albumin (g/dL)*4.3 ± 0.51
Direct Bilirubin (mg/dL)*0.27 ± 0.14
Total Bilirubin (mg/dL)*0.72 ± 0.26
AFP (ng/ml)#2.5 (0.1-33.7)
Hepatitis C Viral load (IU/mL)#165 000 (4 320 - 3 520 000)
Anti-schistosomal Ab + ve5 (9.6)
Fibrosis score
  Low37 (71%)
  High15 (29%)

 

Table 2. Comparison Between Anti-H. pylori IgG Positive and Negative Patients Regarding Demographic and Laboratory Data
 
Anti-H.pylori IgG + ve (n = 31)Anti-H.pylori IgG - ve (n = 21)P-value
amean ± SD; bnumber (%); cmedian (range).
Age (year)a42.3 ± 6.942.9 ± 8.20.78
Genderb
  Male24(77.4)15 (71.4)
  Female7(22.6)6 (28.6)0.75
ALT (IU/L)a56.4 ± 27.557.4 ± 39.40.91
AST (IU/L)a49.3 ± 20.752.8 ± 30.20.62
Albumin (g/dL)a4.3 ± 0.54.4 ± 0.50.48
Direct bilirubin (mg/dL)a0.25 ± 0.130.31 ± 0.150.13
Total bilirubin (mg/dL)a0.72 ± 0.300.74 ± 0.20.79
AFP (ng/ml)c2.9 (0.5 - 32.9)2 (0.1 - 33.7)0.48
HCV Viral load (IU/mL)c95 700 (4 350 – 3 520 000)225 000 (12 800 – 2 688 483)0.18
Anti-schistosomal Ab + veb3 (9.7)2 (9.5)0.64
Fibrosis Scoringb
  Low stage21 (67.7)16 (76.2)
  High stage10 (32.3)5 (23.8)0.51

 

Table 3. Comparison Between H. pylori DNA Positive and Negative Patients Regarding Demographic and Laboratory Data
 
H.Pylori DNA + ve (n = 6)H.Pylori DNA – ve (n = 46)P-value
amean ± SD; bnumber (%); cmedian (range).
Age (year)a45.6 ± 5.842.1 ± 7.50.28
Genderb
  Male5 (83.3)34 (74)
  Female1 (16.7)12 (26)1.0
ALT (IU/L)a64.3 ± 42.355.9 ± 31.50.56
AST (IU/L)a57 ± 24.749.9 ± 24.90.51
Albumin (g/dL)a4.6 ± 0.44.3 ± 0.50.17
Direct bilirubin (mg/dL)a0.25 ± 0.140.28 ± 0.150.65
Total bilirubin (mg/dL)a0.9 ± 0.470.7 ± 0.220.078
AFP (ng/mL)c3.5 (0.5 - 32.9)2.2 (0.1 - 33.7)0.75
HCV Viral load (IU/mL)c337 000 (51 200 - 3 520 000)165 000 (4 320 – 2 688 483)0.40
Fibrosis Scoringb
  Low stage1 (16.7)36 (78.3)
  High stage5 (83.3)10 (21.7)0.0057