Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 4, Number 1, February 2011, pages 13-19


Significance of Serum Alpha-Glutathione S-Transferase Assessment in Hepatitis C Patients with Different Alanine Aminotransferase Patterns

Tables

Table 1. Comparison Between the Mean ± SD of HCV RNA, ALT, AST, ALP, GGT, TP, Alb, and α-GST Levels in the Study Groups.
 
Control (n = 21)NALT (n = 12)NNALT (n = 29)HALT (n = 24)All HCV (n = 65)
P: comparison between various patients groups and control. NALT: normal ALT group (ALT < 40 IU/L); NNALT: near normal ALT group (40 - 80 IU/L); HALT: high ALT group (ALT > 80 IU/L); α-GST: Alpha-Glutathione S-transferase; n: number; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; GGT: gamma glutamyl-transferase; TP: total proteins; Alb: albumin; HCV: hepatitis C virus.
HCV RNA (IU/ml (x104)) P0.001.56 ± 2.8 0.00016.71 ± 23.3 0.00032.38 ± 40.5 0.00019.70 ± 30.9 0.000
ALT (IU/L) P25.29 ± 7.130.08 ± 5.8 0.51461.45 ± 11.5 0.028132.42 ± 53.3 < 0.00181.86 ± 52.3 < 0.001
AST (IU/L) P24.26 ± 6.627.75 ± 5.1 0.38445.45 ± 9.5 0.03597.92 ± 46.7 < 0.00161.55 ± 40.7 < 0.001
ALP (IU/L) P164.52 ± 40.9171.25 ± 40.3 1.000191.62 ± 41.2 0.991225.17 ± 65.1 0.040200.25 ± 54.5 < 0.001
GGT (IU/L) P32.86 ± 8.234.42 ± 8.5 0.87247.69 ± 14.6 0.04882.21 ± 40.7 < 0.00157.99 ± 32.8 < 0.001
TP (g/dl) P7.40 ± 0.57.10 ± 0.5 0.9206.69 ± 0.6 0.5216.52 ± 0.5 0.9726.71 ± 0.6 0.602
Alb (g/dl) P4.61 ± 0.64.23 ± 0.6 0.9473.86 ± 0.5 0.6073.45 ± 0.5 0.2463.78 ± 0.6 1.038
α-GST (ng/ml) P0.27 ± 2.110.51 ± 3.4 0.01916.25 ± 7.7 < 0.00118.56 ± 9.7 < 0.00116.04 ± 8.4 < 0.001

 

Table 2. Correlation Analysis Between α-GST and HCV RNA, ALT, AST, ALP, GGT, TP, and Alb Levels in the Study Groups.
 
HCV RNAALTASTALPGGTTPAlb
NALT: normal ALT group (ALT < 40 IU/L); NNALT: near normal ALT group (40 - 80 IU/L); HALT: high ALT group (ALT > 80 IU/L); α-GST: Alpha-Glutathione S-transferase; n: number; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; GGT: gamma glutamyl-transferase; TP: total proteins; Alb: albumin; HCV: hepatitis C virus.
NALTr0.750.6860.2690.50050.562- 0.322- 0.265
P< 0.05< 0.05> 0.05> 0.05> 0.05> 0.05> 0.05
NNALTr0.5230.7630.7370.4990.698- 0.443- 0.419
P< 0.05< 0.01< 0.01> 0.05< 0.01> 0.05> 0.05
HALTr0.5320.9090.8110.6980.773- 0.495- 0.502
P< 0.01< 0.01< 0.01< 0.01< 0.01> 0.05> 0.05
ALLr0.6450.6850.6570.5490.594- 0.443- 0.419
HCVP< 0.01< 0.01< 0.01< 0.01< 0.01> 0.05> 0.05

 

Table 3. Sensitivity, Specificity, Positive Predictive Value and Negative Predictive Value of HCV RNA, ALT, AST, ALP, GGT, TP, Alb, and α-GST in all the HCV Patients Groups and Control.
 
Sensitivity %Specificity %+ ve predictive- ve predictive
Value%Value%
n = number of cases.
HCV All Patients (n = 65)
HCV RNA70.7777.91100.0052.50
ALT81.5486.05100.0063.64
AST64.6273.26100.0047.73
ALP9.2331.40100.0026.25
GGT46.1559.30100.0037.50
TP12.3133.72100.0026.92
Alb33.8550.00100.0032.81
α-GST81.5484.8898.1562.50
NALT Group (n = 12)
HCV RNA41.6778.79100.0075.00
ALT0.0063.640.0063.64
AST0.0063.640.0063.64
ALP0.0063.640.0063.64
GGT0.0063.640.0063.64
TP0.0063.640.0063.64
Alb0.0063.640.0063.64
α-GST66.6784.8588.8983.33
NNALT Group (n = 29)
HCV RNA75.886.00100.0075.00
ALT100.00100.00100.00100.00
AST62.0778.00100.0065.63
ALP0.0042.000.0042.00
GGT41.3866.00100.0055.26
TP13.7950.00100.0045.65
Alb27.5958.00100.0050.00
α-GST79.3186.0095.8376.92
HALT Group (n = 24)
HCV RNA79.1788.89100.0080.77
ALT100.00100.00100.00100.00
AST100.00100.00100.00100.00
ALP25.0060.00100.0053.85
GGT75.0086.67100.0077.78
TP16.6755.56100.0051.22
Alb58.3377.78100.0067.74
α-GST91.6793.3395.6590.91