Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 3, Number 4, August 2010, pages 151-155

Effect of Traditional Japanese Medicine, Daikenchuto (TJ-100) in Patients With Chronic Constipation

**Table 1.** Demographic and Baseline Characteristics of 22 Patients With Chronic Constipation
Group	7.5 g/day (N = 14)	15 g/day (N = 8)
Gender (male/female)	8/6	4/4	0.69
Age (years) (mean ± SD)	69.2 ± 13	68.9 ± 16	0.86
Mean duration of symptoms prior to diagnosis (month)	18	19	0.88

Table 1. Demographic and Baseline Characteristics of 22 Patients With Chronic Constipation

Group

7.5 g/day (N = 14)

15 g/day (N = 8)

Gender (male/female)

8/6

4/4

0.69

Age (years) (mean ± SD)

69.2 ± 13

68.9 ± 16

0.86

Mean duration of symptoms prior to diagnosis (month)

0.88

**Table 2.** Bowel Movement Frequency
	TJ-100
The frequency of bowel movement at 0, 4, 6 and 8 week is shown as the median/day of the week. Data are shown as median (interquartile range). p value shows the difference between 0 week and 4, 6, or 8 weeks
0 week	0.7 (0.3)		0.9 (0.4)
4 weeks	0.9 (0.2)	0.05	0.9 (0.3)	0.25
6 weeks	0.9 (0.4)	0.66	0.9 (0.2)	0.09
8 weeks	0.9 (0.3)	0.34	1 (0.2)	0.63

Table 2. Bowel Movement Frequency

TJ-100

7.5 g/day (N = 14)

p value

15g/day (N = 8)

p value

The frequency of bowel movement at 0, 4, 6 and 8 week is shown as the median/day of the week. Data are shown as median (interquartile range). p value shows the difference between 0 week and 4, 6, or 8 weeks

0 week

0.7 (0.3)

0.9 (0.4)

4 weeks

0.9 (0.2)

0.05

0.9 (0.3)

0.25

6 weeks

0.9 (0.4)

0.66

0.9 (0.2)

0.09

8 weeks

0.9 (0.3)

0.34

1 (0.2)

0.63

**Table 3.** Abdominal Bloating
	TJ-100
The degree of bloating before and after the treatment of two doses of TJ-100 (7.5 g/day and 15 g/day) is shown using visual analogue scale (VAS) score (0-100; 0, none).
Data are shown as median (interquartile range). p value shows the difference between 0 week and 4, 6, or 8 weeks.
0 week	55 (27)		69 (13)
4 weeks	20 (21)	0.006	35 (16)	0.007
6 weeks	17 (18)	0.007	21 (14)	0.007
8 weeks	19 (17)	0.005	15 (8)	0.007

Table 3. Abdominal Bloating

TJ-100

7.5 g/day (N = 14)

p value

15 g/day (N = 8)

p value

The degree of bloating before and after the treatment of two doses of TJ-100 (7.5 g/day and 15 g/day) is shown using visual analogue scale (VAS) score (0-100; 0, none).

Data are shown as median (interquartile range). p value shows the difference between 0 week and 4, 6, or 8 weeks.

0 week

55 (27)

69 (13)

4 weeks

20 (21)

0.006

35 (16)

0.007

6 weeks

17 (18)

0.007

21 (14)

0.007

8 weeks

19 (17)

0.005

15 (8)

0.007

**Table 4.** Abdominal Pain
	TJ-100
The degree of abdominal pain before and after the treatment of two doses of TJ-100 (7.5 g/day and 15 g/day) is shown using visual analogue scale (VAS) score (0-100; 0, none).
Data are shown as median (interquartile range). p value shows the difference between 0 week and 4, 6, or 8 weeks.
0 week	20 (31)		32 (25)
4 weeks	16 (19)	0.04	9 (12)	0.02
6 weeks	13 (16)	0.12	7 (12)	0.02
8 weeks	19 (14)	0.13	7 (6)	0.03

Table 4. Abdominal Pain

TJ-100

7.5 g/day (N = 14)

p value

15 g/day (N = 8)

p value

The degree of abdominal pain before and after the treatment of two doses of TJ-100 (7.5 g/day and 15 g/day) is shown using visual analogue scale (VAS) score (0-100; 0, none).

Data are shown as median (interquartile range). p value shows the difference between 0 week and 4, 6, or 8 weeks.

0 week

20 (31)

32 (25)

4 weeks

16 (19)

0.04

9 (12)

0.02

6 weeks

13 (16)

0.12

7 (12)

0.02

8 weeks

19 (14)

0.13

7 (6)

0.03

**Table 5.** Gastrointestinal symptoms rating scale (GSRS)
	TJ-100
The change of gastrointestinal symptoms rating scale (GSRS) (1-5; 1, none) before and after the treatment of two doses of TJ-100 (7.5 g/day and 15 g/day) is shown.
Data are shown as median (interquartile range). p value shows the difference between 0 week and 4, 6, or 8 weeks.
0 week	2.6 (0.6)		2.8 (0.5)
4 weeks	2.2 (0.5)	0.002	2.3 (0.3)	0.008
6 weeks	2.2 (0.5)	0.0002	2.3 (0.4)	0.008
8 weeks	2.3 (0.5)	0.003	2.2 (0.4)	0.008

Table 5. Gastrointestinal symptoms rating scale (GSRS)

TJ-100

7.5 g/day (N = 14)

p value

15 g/day (N = 8)

p value

The change of gastrointestinal symptoms rating scale (GSRS) (1-5; 1, none) before and after the treatment of two doses of TJ-100 (7.5 g/day and 15 g/day) is shown.

Data are shown as median (interquartile range). p value shows the difference between 0 week and 4, 6, or 8 weeks.

0 week

2.6 (0.6)

2.8 (0.5)

4 weeks

2.2 (0.5)

0.002

2.3 (0.3)

0.008

6 weeks

2.2 (0.5)

0.0002

2.3 (0.4)

0.008

8 weeks

2.3 (0.5)

0.003

2.2 (0.4)

0.008