Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
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Case Report

Volume 3, Number 4, August 2010, pages 180-184


Primary Small Cell Carcinoma of Liver: A Rare Tumor

Figures

Figure 1.
Figure 1. Contrast enhanced computed tomography (CECT) abdomen revealed 13.2 x 13.5 x 7.3 cm well defined mass lesion involving segment IV, V and VIII of liver. There was rim enhancement on arterial phase and no contrast retention on venous phase.
Figure 2.
Figure 2. Photomicrograph showing A: Organoid and trabecular pattern of tumor cells separated by thin fibrovascular septa; B: Tumor cells with finely granular nuclear chromatin and scanty cytoplasm (Haematoxylin and eosin, x 100, x 400).
Figure 3.
Figure 3. A-D: Photomicrograph showing A: Pancytokeratin positivity; B: Neuron specific enolase positivity; C: Synaptophysin positivity and D: Hep Par-1 negativity in tumor cells (Immunostains, x 200).

Table

Table 1. Clinicopathological and Immunohistochemical Features of Patients With Primary Small Cell Carcinoma of the Liver
 
AuthorAge /SexSymptomSize (cm)Stage of DiseaseAFP (ng/ml)Immunohistochemical StainingTreatment
RUQ, Right upper quadrant; DM, Diabetes mellitus; CT, Chemotherapy; AFP, Alpha-fetoprotein; CEA, Carcinoembryonic antigen; CHR, Chromogranin; CK, Cytokeratin; EMA, Epithelial membrane antigen; NSE, Neuron-specific enolase; SYN, Synaptophysin; TTF-1, Thyroid transcription factor 1.
Ryu et al [11]56/MRUQ pain, general weakness8 cmAdvanced3.24(+) CD56, C-kit, SYN; (-) TTF-1CT (cisplatin, etoposide, irinotecan)
Kim et al [10]53/MPalpable mass12 cmAdvanced2.94(+) CD56, NSE, C-kit, SYN, mixed CK, EMA; (-) CK7, 8, 19, 20, AFP, CEA, hepatocyte, vimentin, desmin, TTF-1Segmentectomy and CT (cisplatin, etoposide)
Zanconati et al [8]56/MAbdominal discomfort5 cmLimited> 200(+) AE1/AE3, CK8, 18, 19, NSE, AFP, ERY-1; (-) S-100 protein, CEAPartial hepatectomy
Zanconati et al [8]69/MDM, weight loss10 cmAdvanced-(+) AE1/AE3, CK 8, 18, 19; (+/-) NSE, CHR; (-) S-100 protein, CEA-
Zanconati et al [8]89/MJaundice6 cmAdvanced150(+) AE1/AE3, CK 8, 18, 19, AFP, NSE; (-) CHR, S-100 protein, CEA-
Kim et al [13]67/MAbdominal discomfort12 cmAdvanced-(+) SYN, CD56, C-kit; (-) CK, CEA, AFPCT (cisplatin, epirubicin)
Sengoz et al [9]73/F-Advanced-Right hepatectomy
Sengoz et al [9]66/M---CT (Cisplatin)
Kim et al [2]-Advanced(+) CHR, SYN-
Choi et al [12]82/FAbdominal discomfort6.7 cmAdvanced3.4(+) CD56, NSE, SYN, CHR,TTF-1, C-kit; (-) Antihepatocyte, AFP,vimentin, desmin, CK7, 19, 20, CEA, S-100 proteinSegmentectomy of liver and CT (etoposide)
Morikawa et al [15]77/MGeneral fatigue and breathlessness10 cmAdvanced27(+)AE1/AE5, CAM5.2; (-) NSE, desmin, vimentin, CEACT (cisplatin, etoposide)
Yang-Qing Huang et al [14]34/MIncidental detection--Right hepatectomy and segment I excision and TACE for recurrance
Index case40/FPain and lump abdomen13.5 cmAdvanced2.1(+) NSE, SYN; (-) TTF1, hep-par 1, CEACentral bisectionectomy and CT (cisplatin, etoposide)