Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 3, Number 3, June 2010, pages 101-105

A RecQ Protein-like 5 Haplotype is Associated With Colon Cancer

Tables

**Table 1.** Kentucky Colon Cancer Study Demographics
Variables, Mean (SD) or n (%)	Cases (n = 390)	Controls (n = 464)	p-valuea
^aStudent’s t-test or chi-square for differences, complete data on covariates available for 340 cases and 415 controls.
^bUse at least twice per week ≥ 6 months.
Age, yr	63.0 (10.5)	58.1 (11.1)	0.001
Male	196 (50)	170 (37)
Female	194 (50)	294 (63)	0.001
Regular NSAID useb	217 (64)	290 (70)	0.08
Family history of colorectal cancer	86 (25)	62 (15)	0.001
Body mass index (kg/m²)	29.2 (6.3)	27.9 (5.8)	0.002

**Table 2.** Allele and Genotype Frequencies and Association Tests for *RECQL5* SNPs
SNP	Total	Genotype			MAF	Allele χ², p-value	Crude OR (95% CI)	Adjusted ORa (95% CI)
^aPer allele odds ratios adjusted for age, sex, BMI, NSAID use and family history of colorectal cancer.
rs820196		TT	TC	CC	C
Cases	390	0.58	0.36	0.06	0.24	0.27, 0.60	1.06 (0.85, 1.32)	1.05 (0.83, 1.34)
Controls	464	0.60	0.34	0.06	0.23
rs4789223		AA	AG	GG	G
Cases	390	0.34	0.45	0.21	0.43	3.42, 0.07	1.19 (0.98, 1.43)	1.21 (0.98, 1.49)
Controls	464	0.38	0.46	0.16	0.39

**Table 3.** *RECQL5* Colon Cancer Haplotype Association Tests
rs820196-rs4789223 haplotypea	Case frequency	Control frequency	OR (95% CI), p-value	Adjusted OR (95% CI),b p-value
^aC-A haplotype too rare to consider; frequency of 0.001 in cases, absent in controls.
^bAdjusted for age, sex, BMI, NSAID use and family history of colorectal cancer.
T-A (common alleles)	0.57	0.61	1.0 (reference)	1.0 (reference)
C-G (2 minor alleles)	0.23	0.23	1.13 (0.83, 1.37), 0.62	1.13 (0.87, 1.47), 0.72
T-G	0.20	0.16	1.34 (1.02, 1.76), 0.05	1.39 (1.04, 1.87), 0.04