Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Case Report

Volume 3, Number 3, June 2010, pages 139-143

Follicular Dendritic Cell Tumor in Liver: A Case Report and Collective Review

Figure 1. (a) Enhanced abdominalCT of horizontal view which revealed huge hepatic hypervascular mass of about 14 cm in size (arrow). (b) Enhanced abdominalCT of coronal view which revealed huge hepatic hypervascular mass of about 14 cm in size.(arrow). (c) Angiography revealed the mass was mainly supplied by the left hepatic(arrow). (d) Macroscopic view of the resected follicular dendritic cell tumor of liver as a round softmass and on cut section shows whitish to pinkish surface without centralnecrosis.

Figure 2. (a) Microscopic appearance of follicular dendritic cell tumor. At low magnification, the tumorcells in whorls pattern show hypechromatism and pleomorphism, and interspersedplasma cells and lymphocytes. Higher magnification demonstrates slight eosinophilic cytoplasm, rare mitosis, and indistinct cell borders with granular chromatin and small nucleoli. (b) Immunohistochemical staining for CD 21, the spindle-shaped tumor cells show long cytoplasmic processes which stain brownish. (c) Immunohistochemical staining for CD 35, a marker for follicular dendritic cells reveals tumor cells stained brownish. (d) Positive expression of EBV nuclear RNA on tumor cells by in situ hybridization.

**Table 1.** The Clinical Manifestation of Collective Cases With FDC Tumor
Case	Age (y/o)	Gender	Clinical Presentation	Maximal size (cm)	EBV	Treatment	Reference
+: positive; -: negative; NA: Not available; *:the metastatic cases; EBV: Epstein-Barr Virus; #: well response to chemotherapy.
1	68	F	Malaise, weight loss, anemia	11	+	Chemotherapy; partial hepatectomy	[11]
2	35	F	Epigastric discomfort, fever, weight loss	20	+	Right hemihepatectomy	[5]
3	37	M	Malaise, weight loss	15	+	Right trisegmentectomy with caudate lobectomy	[16]
4	19	F	R't upper quadrant pain, weight loss, palpable abdominal mass	12	+	Excision	[18]
5	56	F	Gastrointestinal upset	15	+	Resection	[18]
6	40	F	Epigastric pain, weight loss	12.5	+	Left hepatectomy	[18]
7	49	F	Liver mass on ultrasound during routine health check-up	4.2	+	Excision	[18]
8	31	F	Abdominal distention, weight loss	15	+	Right hemihepatectomy	[18]
9	57	F	Epigastralgia	9.5	+	Right hemihepatectomy	[17]
10	51	F	Abdominal discomfort, weight loss	12	+	Left lobectomy	[18]
11	30	F	Liver mass on ultrasound during routine health check-up	5.5	+	Right lobectomy	[19]
12	82	M	Liver mass on abdominal CT scan during evaluation of renal calculi; weight loss, weakness	10	-	Right lobectomy	[21]
13	57	F	Abdominal pain, dizziness, vomiting	NA	+	Resection	[4]
*14	70	M	Abdominal pain, weight loss	2.5	-	NA	[6]
*15	65	F	Staging workup showed lesion in liver from abdominal CT	2	NA	Resection	[7]
*16	19	M	Right upper quadrant pain	16	NA	Chemotherapy^#	[8]
17	36	F	Epigastric discomfort	14	+	Left Lateral segmental hepatectomy	Present case

Table 1. The Clinical Manifestation of Collective Cases With FDC Tumor

Case

Age (y/o)

Gender

Clinical Presentation

Maximal size (cm)

EBV

Treatment

Reference

+: positive; -: negative; NA: Not available; *:the metastatic cases; EBV: Epstein-Barr Virus; #: well response to chemotherapy.

Malaise, weight loss, anemia

Chemotherapy; partial hepatectomy

[11]

Epigastric discomfort, fever, weight loss

Right hemihepatectomy

[5]

Malaise, weight loss

Right trisegmentectomy with caudate lobectomy

[16]

R't upper quadrant pain, weight loss, palpable abdominal mass

Excision

[18]

Gastrointestinal upset

Resection

[18]

Epigastric pain, weight loss

12.5

Left hepatectomy

[18]

Liver mass on ultrasound during routine health check-up

4.2

Excision

[18]

Abdominal distention, weight loss

Right hemihepatectomy

[18]

Epigastralgia

9.5

Right hemihepatectomy

[17]

Abdominal discomfort, weight loss

Left lobectomy

[18]

Liver mass on ultrasound during routine health check-up

5.5

Right lobectomy

[19]

Liver mass on abdominal CT scan during evaluation of renal calculi; weight loss, weakness

Right lobectomy

[21]

Abdominal pain, dizziness, vomiting

Resection

[4]

*14

Abdominal pain, weight loss

2.5

[6]

*15

Staging workup showed lesion in liver from abdominal CT

Resection

[7]

*16

Right upper quadrant pain

Chemotherapy^#

[8]

Epigastric discomfort

Left Lateral segmental hepatectomy

Present case