Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 3, Number 2, April 2010, pages 86-90

Regenerative Potential of Aqueous Extract of Neem Azadirachta indica on the Stomach and Ileum Following Ethanol-induced Mucosa Lesion in Adult Wistar Rats

Figures

Figure 1.
Figure 1. Photomicrograph of (a) Stomach (b) Ileum of ethanolic-treated group (group B) (Mag. x 100). Note the disorganization of the mucosa (M) and the ulceration of the epithelium (E) in (a) and (b) as compared with Fig. 2.
Figure 2.
Figure 2. Photomicrograph of (a) Stomach (b) ileum of control (group A) (Mag. x 100). Note the well organized mucosa (M) and well preserved epithelium (E) in (a) and (b).
Figure 3.
Figure 3. Photomicrograph of (a) Stomach (b) Ileum of treated (group C) (Mag. x 100). Note the distinct glandular elements of the mucosa (M) and the restoration of the mucus and epithelium (E) in (a) and (b) as compared with Fig. 2.

Tables

Table 1. Showing the Micromorphometry of the Stomach (M ± SEM)
 
Measured ParametersControl(Group A)1.0 ml of 50% Ethanol (Group B)1.0 ml of 50% Ethanol + 500 mg/kg Neem (Group C)
n = 5; *P < 0.05 (significant) vs. control; §P < 0.05 (significant) group B vs. group C.
Stomach Mucosa (µm)776 ± 25.37526 ± 23.01*602 ± 22.20*§
Stomach Muscularis externa (µm)528 ± 24.24311 ± 21.11*401 ± 22.22*§

 

n = 5; *P < 0.05 (significant) vs. control; §P < 0.05 (significant) group B vs. group C.
Table 2. Showing the Micromorphometry of the Ileum (M ± SEM)
 
Measured ParametersControl(Group A)1.0ml of 50% Ethanol (Group B)1.0ml of 50% Ethanol + 500 mg/kg Neem (Group C)
Ileum Mucosa (µm)281 ± 31.43101 ± 29.42*212 ± 29.58*§
Ileum Muscularis externa (µm)63 ± 11.1641 ± 8.11*54 ± 10.13*§