Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 2, Number 5, October 2009, pages 295-302

Comparative Hepatoprotective Effect of Vitamins A and E Against Gasoline Vapor Toxicity in Male and Female Rats

Figure 1. Comparative effect of gasoline vapors on some liver function diagnostic indices in male and female rats.

Figure 2. Comparative effect of vitamins A and E on comparative percentage changes in some liver function diagnostic indices in male and female rats exposed to gasoline vapors.

**Table 1.** Effect of vitamins A and E on the activities of some liver function diagnostic serum indices in male rats exposed to gasoline vapors
Group	ALT (U/L)	AST (U/L)	GGT (U/L)	ALP (U/L)	Bilirubin (µmol/L)	Total Protein(mg/dl)
Values are presented as mean ± SEM, n = 6, P < 0.05 compared with group I (control); ⁺P < 0.05 compared with group II; *P < 0.05 compared with group III; ^#P > 0.05 compared with group I. Mc = male control; Mt = male test, exposed to gasoline vapors only; MvitA = male test treated with vitamin A; MvitE = male test treated with vitamin E.
I (Mc)	10.01 ± 2.14	20.67 ± 2.72	28.75 ± 2.30	269.65 ± 12.10	2.84 ± 0.60	6.75 ± 1.50
II (Mt)	25.05 ± 2.10*	40.25 ± 1.80*	88.20 ± 3.20*	408.36 ± 16.22*	8.06 ± 1.02*	2.85 ± 2.74*
III (MvitA)	11.25 ± 2.24^+,#	22.02 ±1.60^+,#	29.87 ± 2.34^+,#	270.10 ± 20.16^+,#	3.02 ± 2.10^+,#	5.92 ± 2.60^+,#
IV (MvitE)	9.05 ± 2.53**^,#	19.85 ± 1.30**^,#	27.96 ± 1.96**^,#	267.98 ± 20.23**^,#	2.38 ± 0.3 **^,#	6.62 ± 2.56**^,#

Table 1. Effect of vitamins A and E on the activities of some liver function diagnostic serum indices in male rats exposed to gasoline vapors

Group

ALT (U/L)

AST (U/L)

GGT (U/L)

ALP (U/L)

Bilirubin (µmol/L)

Total Protein(mg/dl)

Values are presented as mean ± SEM, n = 6, *P < 0.05 compared with group I (control); ⁺P < 0.05 compared with group II; **P < 0.05 compared with group III; ^#P > 0.05 compared with group I. Mc = male control; Mt = male test, exposed to gasoline vapors only; MvitA = male test treated with vitamin A; MvitE = male test treated with vitamin E.

I (Mc)

10.01 ± 2.14

20.67 ± 2.72

28.75 ± 2.30

269.65 ± 12.10

2.84 ± 0.60

6.75 ± 1.50

II (Mt)

25.05 ± 2.10*

40.25 ± 1.80*

88.20 ± 3.20*

408.36 ± 16.22*

8.06 ± 1.02*

2.85 ± 2.74*

III (MvitA)

11.25 ± 2.24^+,#

22.02 ±1.60^+,#

29.87 ± 2.34^+,#

270.10 ± 20.16^+,#

3.02 ± 2.10^+,#

5.92 ± 2.60^+,#

IV (MvitE)

9.05 ± 2.53**^,#

19.85 ± 1.30**^,#

27.96 ± 1.96**^,#

267.98 ± 20.23**^,#

2.38 ± 0.3 **^,#

6.62 ± 2.56**^,#

**Table 2.** Effect of vitamins A and E on the activities of some liver function diagnostic serum indices in female rats exposed to gasoline vapors
Group	ALT (U/L)	AST (U/L)	GGT (U/L)	ALP (U/L)	Bilirubin (µmol/L)	Total Protein (mg/dl)
Values are presented as mean ± SEM, n = 6, P < 0.05 compared with group I (control); ⁺P < 0.05 compared with group II; *P < 0.05 compared with group III; ^#P > 0.05 compared with group I. Fc = female control; Ft = female test, exposed to gasoline vapours only; FvitA = female test treated with vitamin A; FvitE = female test treated with vitamin E.
V (Fc)	9.35 ± 2.06	20.02 ± 2.46	27.73 ± 2.83	268.85 ± 13.12	2.56 ± 0.85	5.96 ± 1.82
VI (Ft)	27.18 ± 2.31*	41.01 ± 1.46*	90.01 ± 4.32*	411.63 ± 17.42*	8.38 ± 1.32*	2.55 ± 2.74*
VII (FvitA)	10.02 ± 2.24^+,#	21.68 ± 2.06^+,#	28.58 ± 2.83^+,#	271.16 ± 18.15^+,#	3.38 ± 2.10^+,#	5.58 ± 2.60^+,#
VIII (FvitE)	8.46 ± 2.53**^,#	18.26 ± 1.23**^,#	26.86 ± 2.06**^,#	266.94 ± 20.52**^,#	2.26 ± 0.3 **^,#	6.82 ± 2.56**^,#

Table 2. Effect of vitamins A and E on the activities of some liver function diagnostic serum indices in female rats exposed to gasoline vapors

Group

ALT (U/L)

AST (U/L)

GGT (U/L)

ALP (U/L)

Bilirubin (µmol/L)

Total Protein (mg/dl)

Values are presented as mean ± SEM, n = 6, *P < 0.05 compared with group I (control); ⁺P < 0.05 compared with group II; **P < 0.05 compared with group III; ^#P > 0.05 compared with group I. Fc = female control; Ft = female test, exposed to gasoline vapours only; FvitA = female test treated with vitamin A; FvitE = female test treated with vitamin E.

V (Fc)

9.35 ± 2.06

20.02 ± 2.46

27.73 ± 2.83

268.85 ± 13.12

2.56 ± 0.85

5.96 ± 1.82

VI (Ft)

27.18 ± 2.31*

41.01 ± 1.46*

90.01 ± 4.32*

411.63 ± 17.42*

8.38 ± 1.32*

2.55 ± 2.74*

VII (FvitA)

10.02 ± 2.24^+,#

21.68 ± 2.06^+,#

28.58 ± 2.83^+,#

271.16 ± 18.15^+,#

3.38 ± 2.10^+,#

5.58 ± 2.60^+,#

VIII (FvitE)

8.46 ± 2.53**^,#

18.26 ± 1.23**^,#

26.86 ± 2.06**^,#

266.94 ± 20.52**^,#

2.26 ± 0.3 **^,#

6.82 ± 2.56**^,#