Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 2, Number 4, August 2009, pages 213-219

Plasma Actin-free Gc-globulin in Patients with Chronic or Acute-on-chronic Liver Failure Caused by Hepatitis B Virus

**Table 1.** Clinical characteristics of the study populations, median (range)
Characteristic	CLF	ACLF	CR	Healthy
CLF, chronic liver failure; ACLF, acute on chronic liver failure; CR: cirrhosis
No.	33	23	23	25
Age (yr), median (range)	54 (35 – 79)	50 (27 – 74)	54 (39 – 74)	34 (24 – 62)
Gender (M:F)	23:10	21:2	20:3	19:6
Cause	HBV (33)	HBV (23)	HBV (23)	HBV (0)
AST (IU/L)	57 (20 – 459)	296 (24 – 1611)	44 (22 – 201)
ALB (g/L)	25 (17 – 41)	28 (21 – 34)	34 (31 – 38)
CHE (Units)	1346 (697 – 4034)	2251 (522 – 4168)	3457 (3243 – 4814)
TBIL (µmol/L)	162 (63 – 460)	240 (95.7 – 918.4)	39 (19 – 80)
INR	2.46 (1.91 – 5.01)	2.36 (1.89 – 5.67)	1.29 (1.03 – 1.84)
PLT (10⁹/L)	44 (16 – 172)	70 (17 – 166)	88 (31 – 218)
Child-Pugh score	13 (11 – 14)	12 (10 – 13)	8 (6 – 10)

Table 1. Clinical characteristics of the study populations, median (range)

Characteristic

CLF

ACLF

Healthy

CLF, chronic liver failure; ACLF, acute on chronic liver failure; CR: cirrhosis

No.

Age (yr), median (range)

54 (35 – 79)

50 (27 – 74)

54 (39 – 74)

34 (24 – 62)

Gender (M:F)

23:10

21:2

20:3

19:6

Cause

HBV (33)

HBV (23)

HBV (0)

AST (IU/L)

57 (20 – 459)

296 (24 – 1611)

44 (22 – 201)

ALB (g/L)

25 (17 – 41)

28 (21 – 34)

34 (31 – 38)

CHE (Units)

1346 (697 – 4034)

2251 (522 – 4168)

3457 (3243 – 4814)

TBIL (µmol/L)

162 (63 – 460)

240 (95.7 – 918.4)

39 (19 – 80)

INR

2.46 (1.91 – 5.01)

2.36 (1.89 – 5.67)

1.29 (1.03 – 1.84)

PLT (10⁹/L)

44 (16 – 172)

70 (17 – 166)

88 (31 – 218)

Child-Pugh score

13 (11 – 14)

12 (10 – 13)

8 (6 – 10)

**Table 2.** Af-Gc globulin levels in each group
Group	No.	Gender (M:F)	Age (years)	Af-Gc globulin (mg/L)
^aP < 0.001 vs healthy; ^bP < 0.001 vs CR;^cP = 0.001 vs CR;^dP < 0.001 vs ACLF. CLF, chronic liver failure; ACLF, acute on chronic liver failure; CR, cirrhosis
CLF	33	23:10	54 (35 – 79)	52.45 (12.02 – 169.47) ^{a, b, d}
ACLF	23	21:2	50 (27 – 74)	131.17 (53.73 – 374.80) ^{a, c}
CR	23	20:3	54 (39 – 74)	218.40 (98.19 – 389.51) ^a
Control	25	19:6	34 (24 – 62)	301.38 (223.72 – 520.53)

Table 2. Af-Gc globulin levels in each group

Group

No.

Gender (M:F)

Age (years)

Af-Gc globulin (mg/L)

^aP < 0.001 vs healthy; ^bP < 0.001 vs CR;^cP = 0.001 vs CR;^dP < 0.001 vs ACLF. CLF, chronic liver failure; ACLF, acute on chronic liver failure; CR, cirrhosis

CLF

23:10

54 (35 – 79)

52.45 (12.02 – 169.47) ^{a, b, d}

ACLF

21:2

50 (27 – 74)

131.17 (53.73 – 374.80) ^{a, c}

20:3

54 (39 – 74)

218.40 (98.19 – 389.51) ^a

Control

19:6

34 (24 – 62)

301.38 (223.72 – 520.53)

**Table 3.** Correlation Coefficients (r) and P Values of laboratory test vs Af-Gc globulin in liver failure patients
Characteristic	r value	P value
ALB	0.422	0.001
CHE	0.539	< 0.001
ALT	0.428	0.001
AST	0.426	0.001
TBIL	0.245	0.069
INR	– 0.085	0.54
Child-Pugh score	– 0.313	0.02
PLT	0.228	0.097

Table 3. Correlation Coefficients (r) and P Values of laboratory test vs Af-Gc globulin in liver failure patients

Characteristic

r value

P value

ALB

0.422

0.001

CHE

0.539

< 0.001

ALT

0.428

0.001

AST

0.426

0.001

TBIL

0.245

0.069

INR

– 0.085

0.54

Child-Pugh score

– 0.313

0.02

PLT

0.228

0.097

**Table 4.** Af-Gc levels and complications of liver failure, mean (range)
Characteristic	Present (mg/L)	Absent (mg/L)	P value
Encephalopathy	58.83 (12.06 – 374.8)	99.8 (12.02 – 331.67)	0.083
Infection	60.96 (12.02 – 233.14)	104.47 (32.65 – 374.80)	0.015
GI bleeding	66.28 (12.06 – 374.8)	90 (12.02 – 331.67)	0.383

Table 4. Af-Gc levels and complications of liver failure, mean (range)

Characteristic

Present (mg/L)

Absent (mg/L)

P value

Encephalopathy

58.83 (12.06 – 374.8)

99.8 (12.02 – 331.67)

0.083

Infection

60.96 (12.02 – 233.14)

104.47 (32.65 – 374.80)

0.015

GI bleeding

66.28 (12.06 – 374.8)

90 (12.02 – 331.67)

0.383

**Table 5.** Af-Gc levels for prognosis of liver failure, mean (range)
Group	No.	Non-survivors	Survivors	P value
CLF, chronic liver failure; ACLF, acute on chronic liver failure; CR, cirrhosis
LF	56	84.36 (12.06 – 233.14)	83.30 (12.02 – 374.80)	> 0.05
CLF	33	32.65 (12.06 – 169.47)	57.77 (12.02 – 143.94)	> 0.05
ACLF	23	156.18 (90.00 – 233.14)	122.71 (53.73 – 374.80)	> 0.05

Table 5. Af-Gc levels for prognosis of liver failure, mean (range)

Group

No.

Non-survivors

Survivors

P value

CLF, chronic liver failure; ACLF, acute on chronic liver failure; CR, cirrhosis

84.36 (12.06 – 233.14)

83.30 (12.02 – 374.80)

> 0.05

CLF

32.65 (12.06 – 169.47)

57.77 (12.02 – 143.94)

> 0.05

ACLF

156.18 (90.00 – 233.14)

122.71 (53.73 – 374.80)

> 0.05