Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
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Case Report

Volume 2, Number 3, June 2009, pages 183-187

Facing the Challenge of Acute Autoimmune Liver Disease: Report of a Case and Review of the Literature


Figure 1.
Figure 1. Inflammatory infiltration of intra-hepatic bile ducts with the presence of endoepithelial lymphocytes and plasma cells, periductal fibrosis, portal inflammation and canalicular cholestasis (H-E stain, × 200).
Figure 2.
Figure 2. Chronic cholestatic disease characterized by progressive inflammation and fibrosis of intra- and extra-hepatic bile ducts (Masson trichrome stain × 200)


Table 1. Simplified diagnostic criteria for autoimmune hepatitis
ANA: Antinuclear antibody; SMA: Smooth muscle antibody; LKM: Liver/Kidney microsome type; SLA: Soluble liver antigen. Resulting in: ≥ 6: Probable AIH and ≥ 7: Definite AIH. *Addition of points achieved for all autoantibodies (maximum, 2 points).
ANA or SMA≥ 1:401
ANA or SMA≥ 1:80
or LKM≥ 1:402*
or SLAPositive
IgG> Upper normal limit1
> 1.10 times upper normal limit2
Liver histology (evidence of hepatitis is a common condition)Compatible with AIH1
Typical AIH2
Absence of viral hepatitisYes2