Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access |
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc |
Journal website https://www.gastrores.org |
Original Article
Volume 15, Number 6, December 2022, pages 334-342
Hospitalization Outcomes of Acute Pancreatitis in Hematopoietic Stem Cell Transplant Recipients
Figures
Tables
Without pancreatitis | With pancreatitis | P-value | |
---|---|---|---|
Age category | < 0.001 | ||
18 - 45 | 30,045 (21.57) | 360 (42.11) | |
45 - 65 | 63,845 (45.84) | 330 (38.6) | |
> 65 | 45,385 (32.59) | 165 (19.3) | |
Sex | 0.2574 | ||
Male | 79,465 (57.06) | 450 (52.6) | |
Female | 59,810 (42.94) | 405 (47.4) | |
Race | 0.3758 | ||
White | 97,105 (69.72) | 540 (63.16) | |
African American | 17,020 (12.22) | 140 (16.37) | |
Hispanic | 14,695 (10.55) | 110 (12.87) | |
Asian/Pacific islander | 4,405 (3.16) | 35 (4.09) | |
Native American | 475 (0.34) | 0 (0) | |
Other | 5,575 (4.00) | 30 (3.51) | |
Insurance | 0.0491 | ||
Medicare | 53,505 (38.42) | 260 (30.41) | |
Medicaid | 15,735 (11.3) | 180 (21.05) | |
Private | 64,080 (46.01) | 365 (42.69) | |
Underinsured | 1,485 (1.07) | 25 (2.92) | |
Income | 0.2693 | ||
Lowest quartile | 28,760 (20.65) | 190 (22.22) | |
Second quartile | 32,890 (23.62) | 235 (27.49) | |
Third quartile | 37,755 (27.11) | 175 (20.47) | |
Highest quartile | 39,870 (28.63) | 255 (29.82) | |
Region | 0.4801 | ||
Northeast | 29,355 (21.08) | 220 (25.73) | |
Midwest | 34,535 (24.8) | 185 (21.64) | |
South | 46,580 (33.44) | 285 (33.33) | |
West | 28,805 (20.68) | 165 (19.3) | |
Hospital location | 0.0575 | ||
Rural | 2,960 (2.13) | 35 (4.09) | |
Urban | 136,315 (97.85) | 820 (95.91) | |
Hospital teaching status | < 0.001 | ||
Non-teaching hospitals | 14,070 (10.1) | 170 (19.88) | |
Teaching hospitals | 125,205 (89.9) | 685 (80.12) | |
Hospital bed size | 0.007 | ||
Small | 18,035 (12.95) | 120 (14.04) | |
Medium | 24,680 (17.72) | 230 (26.9) | |
Large | 96,560 (69.33) | 505 (59.06) | |
Charlson comorbidities | 0.0001 | ||
0 | 12,480 (8.96) | 135 (15.79) | |
1 | 7,470 (5.36) | 85 (9.94) | |
2 | 56,840 (40.81) | 255 (29.82) | |
> 3 | 62485 (44.86) | 380 (44.44) |
Without pancreatitis | With pancreatitis | P-value | |
---|---|---|---|
aValues less than 11, not to be reported as per HCUP data user agreement (DUA). AP: acute pancreatitis; HSCT: hematopoietic stem cell transplantation; HLH: hemophagocytic lymphohistiocytosis; ERCP: endoscopic retrograde cholangiopancreatography. | |||
Etiologies/complications related to HSCT | |||
Myelodysplastic syndrome | 9,375 (6.73) | 50 (5.85) | 0.641 |
Lymphoid leukemia | 11,595 (8.33) | 120 (14.04) | 0.009 |
Myeloid leukemia | 26,095 (18.74) | 155 (18.13) | 0.842 |
Hodgkin’s lymphoma | 4,430 (3.18) | 20 (2.34) | 0.532 |
Non-Hodgkin’s lymphoma | 3,505 (2.52) | 15 (1.75) | 0.526 |
Bone marrow failure | 30 (0.02) | 0 (0) | 0.846 |
HLH | 290 (0.21) | 0 (0) | 0.569 |
Thalassemia | 290 (0.21) | 0 (0) | 0.57 |
Sickle cell | 1,590 (1.14) | 25 (2.92) | 0.061 |
Metabolism error | 210 (0.15) | 0 (0) | 0.639 |
Primary immunodeficiency | 5,710 (4.1) | 35 (4.09) | 0.997 |
Graft-versus-host disease | 19,390 (13.92) | 185 (21.64) | 0.005 |
Hemolytic uremic syndrome | 130 (0.09) | 0 (0) | 0.726 |
Conditions related to acute pancreatitis | |||
Cholangitis | 660 (0.47) | 55 (6.43) | < 0.001 |
Choledocholithiasis | 1,680 (1.21) | 135 (15.79) | < 0.001 |
Other biliary disorders | 1,680 (1.21) | 55 (6.43) | < 0.001 |
Hypertriglyceridemia | 1,025 (0.74) | 90 (10.53) | < 0.001 |
Hypercalcemia | 2,025 (1.45) | 25 (2.92) | 0.112 |
Systemic lupus erythematosus | 455 (0.33) | a | 0.057 |
Diabetic ketoacidosis | 255 (0.18) | 25 (2.92) | < 0.001 |
Cystic fibrosis | 50 (0.04) | 0 (0) | 0.843 |
Alcohol use | 1,805 (1.3) | 50 (5.85) | < 0.001 |
Abdominal trauma | 225 (0.16) | 0 (0) | 0.607 |
Anomalies of the pancreas | 0 (0) | 20 (2.34) | < 0.001 |
Percutaneous biliary procedures | 25 (0.02) | 0 (0) | 0.881 |
ERCP | 285 (0.2) | 60 (7.02) | < 0.001 |
Without pancreatitis | With pancreatitis | P-value | |
---|---|---|---|
aValues less than 11, not to be reported as per HCUP DUA. A complete table of complications related to HSCT and pancreatitis is not presented due to number of patients for the majority of the categories being less than 11. | |||
Age category | 0.0089 | ||
18 - 45 | 3,795 (28.94) | 70 (56.00) | |
45 - 65 | 6,050 (46.13) | 35 (28.00) | |
> 65 | 3,270 (24.93) | 20 (16.00) | |
Sex | 0.139 | ||
Male | 7,330 (55.89) | 40 (32) | |
Female | 5785 (44.11) | 85 (68) | |
Race | 0.5248 | ||
White | 8,620 (65.73) | 65 (52.00) | |
African American | 1,375 (10.48) | 25 (20.00) | |
Hispanic | 1,660 (12.66) | 25 (20.00) | |
Asian/Pacific islander | 645 (4.77) | a | |
Native American | 40 (0.31) | 0 (0) | |
Other | 795 (6.06) | a | |
Insurance | 0.4607 | ||
Medicare | 3,450 (26.31) | 30 (24.00) | |
Medicaid | 1,810 (13.80) | 40 (32.00) | |
Private | 7,215 (55.01) | 50 (40.00) | |
Underinsured | 95 (0.72) | 0 (0) | |
Income | 0.603 | ||
Lowest quartile | 2,675 (20.40) | 30 (24.00) | |
Second quartile | 2,875 (21.92) | 30 (24.00) | |
Third quartile | 3,590 (27.37) | 20 (16.00) | |
Highest quartile | 3,975 (30.31) | 45 (36.00) | |
Region | 0.0765 | ||
Northeast | 3,125 (23.83) | 55 (44.00) | |
Midwest | 2,800 (21.35) | 20 (16.00) | |
South | 3,930 (29.97) | 20 (16.00) | |
West | 3,260 (24.86) | 30 (24.00) | |
Hospital location | 0.6051 | ||
Rural | a | 0 (0) | |
Urban | 13,105 (99.92) | 125 (100.00) | |
Hospital teaching status | 0.0003 | ||
Non-teaching hospitals | 255 (1.94) | a | |
Teaching hospitals | 12,860 (98.06) | 120 (96.00) | |
Hospital bed size | 0.1696 | ||
Small | 1,380 (10.52) | a | |
Medium | 2,105 (16.05) | 30 (24.00) | |
Large | 9,630 (73.43) | 90 (72.00) | |
Charlson comorbidities | |||
0 | 1,540 (11.74) | a | |
1 | 580 (4.43) | a | |
2 | 5,540 (42.24) | 50 (40) | |
> 3 | 5,455 (41.59) | 60 (48) |