Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
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Original Article

Volume 15, Number 6, December 2022, pages 334-342


Hospitalization Outcomes of Acute Pancreatitis in Hematopoietic Stem Cell Transplant Recipients

Figures

Figure 1.
Figure 1. Inclusion and exclusion flow diagram.
Figure 2.
Figure 2. Categorical outcomes in total hospitalized patients with HSCT, stratified by the presence of acute pancreatitis. *Statistically significant outcomes.

Tables

Table 1. Patient Characteristics and Hospital Demographics of Patients With Hematopoietic Stem Cell Transplantation, Stratified by the Presence of Acute Pancreatitis
 
Without pancreatitisWith pancreatitisP-value
Age category< 0.001
  18 - 4530,045 (21.57)360 (42.11)
  45 - 6563,845 (45.84)330 (38.6)
  > 6545,385 (32.59)165 (19.3)
Sex0.2574
  Male79,465 (57.06)450 (52.6)
  Female59,810 (42.94)405 (47.4)
Race0.3758
  White97,105 (69.72)540 (63.16)
  African American17,020 (12.22)140 (16.37)
  Hispanic14,695 (10.55)110 (12.87)
  Asian/Pacific islander4,405 (3.16)35 (4.09)
  Native American475 (0.34)0 (0)
  Other5,575 (4.00)30 (3.51)
Insurance0.0491
  Medicare53,505 (38.42)260 (30.41)
  Medicaid15,735 (11.3)180 (21.05)
  Private64,080 (46.01)365 (42.69)
  Underinsured1,485 (1.07)25 (2.92)
Income0.2693
  Lowest quartile28,760 (20.65)190 (22.22)
  Second quartile32,890 (23.62)235 (27.49)
  Third quartile37,755 (27.11)175 (20.47)
  Highest quartile39,870 (28.63)255 (29.82)
Region0.4801
  Northeast29,355 (21.08)220 (25.73)
  Midwest34,535 (24.8)185 (21.64)
  South46,580 (33.44)285 (33.33)
  West28,805 (20.68)165 (19.3)
Hospital location0.0575
  Rural2,960 (2.13)35 (4.09)
  Urban136,315 (97.85)820 (95.91)
Hospital teaching status< 0.001
  Non-teaching hospitals14,070 (10.1)170 (19.88)
  Teaching hospitals125,205 (89.9)685 (80.12)
Hospital bed size0.007
  Small18,035 (12.95)120 (14.04)
  Medium24,680 (17.72)230 (26.9)
  Large96,560 (69.33)505 (59.06)
Charlson comorbidities0.0001
  012,480 (8.96)135 (15.79)
  17,470 (5.36)85 (9.94)
  256,840 (40.81)255 (29.82)
  > 362485 (44.86)380 (44.44)

 

Table 2. Complications Related to HSCT and Acute Pancreatitis in HSCT Patients, Stratified by the Presence of AP
 
Without pancreatitisWith pancreatitisP-value
aValues less than 11, not to be reported as per HCUP data user agreement (DUA). AP: acute pancreatitis; HSCT: hematopoietic stem cell transplantation; HLH: hemophagocytic lymphohistiocytosis; ERCP: endoscopic retrograde cholangiopancreatography.
Etiologies/complications related to HSCT
  Myelodysplastic syndrome9,375 (6.73)50 (5.85)0.641
  Lymphoid leukemia11,595 (8.33)120 (14.04)0.009
  Myeloid leukemia26,095 (18.74)155 (18.13)0.842
  Hodgkin’s lymphoma4,430 (3.18)20 (2.34)0.532
  Non-Hodgkin’s lymphoma3,505 (2.52)15 (1.75)0.526
  Bone marrow failure30 (0.02)0 (0)0.846
  HLH290 (0.21)0 (0)0.569
  Thalassemia290 (0.21)0 (0)0.57
  Sickle cell1,590 (1.14)25 (2.92)0.061
  Metabolism error210 (0.15)0 (0)0.639
  Primary immunodeficiency5,710 (4.1)35 (4.09)0.997
  Graft-versus-host disease19,390 (13.92)185 (21.64)0.005
  Hemolytic uremic syndrome130 (0.09)0 (0)0.726
Conditions related to acute pancreatitis
  Cholangitis660 (0.47)55 (6.43)< 0.001
  Choledocholithiasis1,680 (1.21)135 (15.79)< 0.001
  Other biliary disorders1,680 (1.21)55 (6.43)< 0.001
  Hypertriglyceridemia1,025 (0.74)90 (10.53)< 0.001
  Hypercalcemia2,025 (1.45)25 (2.92)0.112
  Systemic lupus erythematosus455 (0.33)a0.057
  Diabetic ketoacidosis255 (0.18)25 (2.92)< 0.001
  Cystic fibrosis50 (0.04)0 (0)0.843
  Alcohol use1,805 (1.3)50 (5.85)< 0.001
  Abdominal trauma225 (0.16)0 (0)0.607
  Anomalies of the pancreas0 (0)20 (2.34)< 0.001
  Percutaneous biliary procedures25 (0.02)0 (0)0.881
  ERCP285 (0.2)60 (7.02)< 0.001

 

Table 3. Patient Characteristics and Hospital Demographics of Patients With Hematopoietic Stem Cell Transplantation, Stratified by the Presence of Acute Pancreatitis
 
Without pancreatitisWith pancreatitisP-value
aValues less than 11, not to be reported as per HCUP DUA. A complete table of complications related to HSCT and pancreatitis is not presented due to number of patients for the majority of the categories being less than 11.
Age category0.0089
  18 - 453,795 (28.94)70 (56.00)
  45 - 656,050 (46.13)35 (28.00)
  > 653,270 (24.93)20 (16.00)
Sex0.139
  Male7,330 (55.89)40 (32)
  Female5785 (44.11)85 (68)
Race0.5248
  White8,620 (65.73)65 (52.00)
  African American1,375 (10.48)25 (20.00)
  Hispanic1,660 (12.66)25 (20.00)
  Asian/Pacific islander645 (4.77)a
  Native American40 (0.31)0 (0)
  Other795 (6.06)a
Insurance0.4607
  Medicare3,450 (26.31)30 (24.00)
  Medicaid1,810 (13.80)40 (32.00)
  Private7,215 (55.01)50 (40.00)
  Underinsured95 (0.72)0 (0)
Income0.603
  Lowest quartile2,675 (20.40)30 (24.00)
  Second quartile2,875 (21.92)30 (24.00)
  Third quartile3,590 (27.37)20 (16.00)
  Highest quartile3,975 (30.31)45 (36.00)
Region0.0765
  Northeast3,125 (23.83)55 (44.00)
  Midwest2,800 (21.35)20 (16.00)
  South3,930 (29.97)20 (16.00)
  West3,260 (24.86)30 (24.00)
Hospital location0.6051
  Rurala0 (0)
  Urban13,105 (99.92)125 (100.00)
Hospital teaching status0.0003
  Non-teaching hospitals255 (1.94)a
  Teaching hospitals12,860 (98.06)120 (96.00)
Hospital bed size0.1696
  Small1,380 (10.52)a
  Medium2,105 (16.05)30 (24.00)
  Large9,630 (73.43)90 (72.00)
Charlson comorbidities
  01,540 (11.74)a
  1580 (4.43)a
  25,540 (42.24)50 (40)
  > 35,455 (41.59)60 (48)