Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website https://www.gastrores.org

Original Article

Volume 15, Number 2, April 2022, pages 75-81

Seasonal Variations of Hospital Admissions for Alcohol-Related Hepatitis in the United States

Figure 1. Daily admission for alcohol-related hepatitis based on each month. July was noted to have the highest number of daily admissions for alcohol-related hepatitis in the country.

Figure 2. Daily mortality for alcohol-related hepatitis based on each month. December was noted to have the highest number of daily mortality.

**Table 1.** Characteristic of Patients Admitted With Alcohol-Related Hepatitis
Variables	N (%)
Mean age (years)	49.5 (49.45 - 49.62)
Age
18 - 44	217,500 (34.47%)
45 - 65	355,575 (56.34%)
> 65	57,975 (9.19%)
Sex
Males	423,785 (67.16%)
Females	207,215 (32.84%)
Race
White	427,630 (70.1%)
Black	60,780 (10%)
Hispanic	80,720 (13.2%)
Asian/Pacific Islander	7,260 (1.19%)
Native American	15,630 (2.56%)
Other	17,440 (2.86%)
Hospital location/teaching
Rural	45,590 (7.22%)
Urban non-teaching	142,475 (22.58%)
Urban teaching	443,005 (70.2%)
Hospital size
Small	132,755 (21.04%)
Medium	188,235 (29.83%)
Large	310,080 (49.14%)
Length of stay	6.42 (6.37 - 6.49)
Total hospitalization charges	65,070.4 (63,828.1 - 66,312.7)

Table 1. Characteristic of Patients Admitted With Alcohol-Related Hepatitis

Variables

N (%)

Mean age (years)

49.5 (49.45 - 49.62)

Age

18 - 44

217,500 (34.47%)

45 - 65

355,575 (56.34%)

> 65

57,975 (9.19%)

Sex

Males

423,785 (67.16%)

Females

207,215 (32.84%)

Race

White

427,630 (70.1%)

Black

60,780 (10%)

Hispanic

80,720 (13.2%)

Asian/Pacific Islander

7,260 (1.19%)

Native American

15,630 (2.56%)

Other

17,440 (2.86%)

Hospital location/teaching

Rural

45,590 (7.22%)

Urban non-teaching

142,475 (22.58%)

Urban teaching

443,005 (70.2%)

Hospital size

Small

132,755 (21.04%)

Medium

188,235 (29.83%)

Large

310,080 (49.14%)

Length of stay

6.42 (6.37 - 6.49)

Total hospitalization charges

65,070.4 (63,828.1 - 66,312.7)

**Table 2.** Incidence Risk Ratio of Alcohol-Related Hepatitis for Each Month
Month	Incidence risk ratio	95% confidence interval	P-value
July was noted to have highest incidence of alcohol-related hepatitis as compared to January. The results were adjusted for patient demographics, hospital characteristics and Charlson comorbidities.
January	Reference
February	0.99	0.97 - 1.03	0.702
March	1.03	1.02 - 1.06	0.034
April	1.08	1.05 - 1.11	< 0.001
May	1.10	1.07 - 1.13	< 0.001
June	1.09	1.06 - 1.12	< 0.001
July	1.15	1.12 - 1.18	< 0.001
August	1.10	1.07 - 1.14	< 0.001
September	1.10	1.07 - 1.14	< 0.001
October	1.07	1.05 - 1.11	< 0.001
November	1.06	1.03 - 1.09	< 0.001
December	1.04	1.01 - 1.07	0.013

Table 2. Incidence Risk Ratio of Alcohol-Related Hepatitis for Each Month

Month

Incidence risk ratio

95% confidence interval

P-value

July was noted to have highest incidence of alcohol-related hepatitis as compared to January. The results were adjusted for patient demographics, hospital characteristics and Charlson comorbidities.

January

Reference

February

0.99

0.97 - 1.03

0.702

March

1.03

1.02 - 1.06

0.034

April

1.08

1.05 - 1.11

< 0.001

May

1.10

1.07 - 1.13

< 0.001

June

1.09

1.06 - 1.12

< 0.001

July

1.15

1.12 - 1.18

< 0.001

August

1.10

1.07 - 1.14

< 0.001

September

1.10

1.07 - 1.14

< 0.001

October

1.07

1.05 - 1.11

< 0.001

November

1.06

1.03 - 1.09

< 0.001

December

1.04

1.01 - 1.07

0.013

**Table 3.** Adjusted Odds Ratio for Each Month With May as a Reference Month
Month	Odds ratio	95% confidence interval	P-value
It is noted that November, December and January have the highest mortality rates after adjusting for confounding factors.
January	1.19	1.05 - 1.35	0.01
February	1.12	0.99 - 1.28	0.08
March	1.12	0.99 - 1.26	0.09
April	1.05	0.92 - 1.19	0.49
May	Reference
June	1.11	0.98 - 1.26	0.10
July	1.11	0.98 - 1.25	0.10
August	1.08	0.96 - 1.22	0.22
September	1.10	0.97 - 1.24	0.16
October	1.08	0.95 - 1.22	0.24
November	1.23	1.09 - 1.40	0.00
December	1.29	1.14 - 1.46	0.00

Table 3. Adjusted Odds Ratio for Each Month With May as a Reference Month

Month

Odds ratio

95% confidence interval

P-value

It is noted that November, December and January have the highest mortality rates after adjusting for confounding factors.

January

1.19

1.05 - 1.35

0.01

February

1.12

0.99 - 1.28

0.08

March

1.12

0.99 - 1.26

0.09

April

1.05

0.92 - 1.19

0.49

May

Reference

June

1.11

0.98 - 1.26

0.10

July

1.11

0.98 - 1.25

0.10

August

1.08

0.96 - 1.22

0.22

September

1.10

0.97 - 1.24

0.16

October

1.08

0.95 - 1.22

0.24

November

1.23

1.09 - 1.40

0.00

December

1.29

1.14 - 1.46

0.00