Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website https://www.gastrores.org

Original Article

Volume 15, Number 1, February 2022, pages 19-25

Clinical Outcomes and Predictors of Thirty-Day Readmissions of Hypertriglyceridemia-Induced Acute Pancreatitis

Figure 1. Kaplan-Meier graph for 30-day all-cause readmissions of hypertriglyceridemia-induced acute pancreatitis (HTG-AP) in the USA in 2018.

**Table 1.** Most Common Principal Diagnosis on Readmission for 30-Day Readmissions of Hypertriglyceridemia-Induced Acute Pancreatitis (HTG-AP) in the USA in 2018
Principal readmission diagnosis (n = 5,773)	Proportion (%)
Acute pancreatitis	45.2
Chronic pancreatitis	6.3
Sepsis (unspecified organism)	4.8
Acute renal failure	1.6
Malignant neoplasm of head of pancreas	1.1
Type 2 diabetes mellitus with ketoacidosis	1.0
Pneumonia (unspecified organism)	0.9
Hypertensive heart disease with heart failure	0.7
Non-ST elevation myocardial infarction	0.7

Table 1. Most Common Principal Diagnosis on Readmission for 30-Day Readmissions of Hypertriglyceridemia-Induced Acute Pancreatitis (HTG-AP) in the USA in 2018

Principal readmission diagnosis (n = 5,773)

Proportion (%)

Acute pancreatitis

45.2

Chronic pancreatitis

6.3

Sepsis (unspecified organism)

4.8

Acute renal failure

1.6

Malignant neoplasm of head of pancreas

1.1

Type 2 diabetes mellitus with ketoacidosis

1.0

Pneumonia (unspecified organism)

0.9

Hypertensive heart disease with heart failure

0.7

Non-ST elevation myocardial infarction

0.7

**Table 2.** Comparison of Hospitalization Characteristics for Index and 30-Day Readmissions of Hypertriglyceridemia-Induced Acute Pancreatitis (HTG-AP) in the USA in 2018
	Index admission of HTG-AP	30-day readmission of HTG-AP	P value
Total hospitalizations	43,094	5,773
Mean age (years)	57.2	57.3	0.914
Gender (%)			0.667
Females	45.3	44.9
Males	54.7	55.1
Charlson comorbidity index score (%)			< 0.001
1	25.6	18.4
2	40.6	33.1
≥ 3	33.8	48.5
Insurance type (%)			< 0.001
Medicaid	44.9	51.2
Medicare	17.0	20.0
Private	33.2	24.4
Uninsured	4.9	4.4
Median annual income, $, (%)			< 0.001
1 - 43,999	30.5	33.9
44,000 - 55,999	29.5	28.9
56,000 - 73,999	24.3	22.7
≥ 74,000	15.7	14.5
Comorbidities
Diabetes mellitus	55.3	53.6	0.070
Hypertension	56.6	50.3	< 0.001
Smoking history	25.0	25.5	0.560
Congestive heart failure	9.3	14.3	< 0.001
Chronic kidney disease	15.5	20.8	< 0.001
Obesity	26.5	21.6	< 0.001
Coronary artery disease	22.3	27.0	< 0.001
Prior cerebrovascular accident	1.2	1.9	< 0.001
Malnutrition	4.9	13.2	< 0.001
Chronic obstructive pulmonary disease	12.3	16.0	< 0.001
Hospital characteristics			< 0.001
Hospital bed size (%)
Small	21.3	17.5
Medium	28.2	26.1
Large	50.5	56.4
Metropolitan location (%)	75.8	78.9
Teaching hospital (%)	63.8	70.4

Table 2. Comparison of Hospitalization Characteristics for Index and 30-Day Readmissions of Hypertriglyceridemia-Induced Acute Pancreatitis (HTG-AP) in the USA in 2018

Index admission of HTG-AP

30-day readmission of HTG-AP

P value

Total hospitalizations

43,094

5,773

Mean age (years)

57.2

57.3

0.914

Gender (%)

0.667

Females

45.3

44.9

Males

54.7

55.1

Charlson comorbidity index score (%)

< 0.001

25.6

18.4

40.6

33.1

≥ 3

33.8

48.5

Insurance type (%)

< 0.001

Medicaid

44.9

51.2

Medicare

17.0

20.0

Private

33.2

24.4

Uninsured

4.9

4.4

Median annual income, $, (%)

< 0.001

1 - 43,999

30.5

33.9

44,000 - 55,999

29.5

28.9

56,000 - 73,999

24.3

22.7

≥ 74,000

15.7

14.5

Comorbidities

Diabetes mellitus

55.3

53.6

0.070

Hypertension

56.6

50.3

< 0.001

Smoking history

25.0

25.5

0.560

Congestive heart failure

9.3

14.3

< 0.001

Chronic kidney disease

15.5

20.8

< 0.001

Obesity

26.5

21.6

< 0.001

Coronary artery disease

22.3

27.0

< 0.001

Prior cerebrovascular accident

1.2

1.9

< 0.001

Malnutrition

4.9

13.2

< 0.001

Chronic obstructive pulmonary disease

12.3

16.0

< 0.001

Hospital characteristics

< 0.001

Hospital bed size (%)

Small

21.3

17.5

Medium

28.2

26.1

Large

50.5

56.4

Metropolitan location (%)

75.8

78.9

Teaching hospital (%)

63.8

70.4

**Table 3.** Comparison of Clinical Outcomes for Index and 30-Day Readmissions of Hypertriglyceridemia-Induced Acute Pancreatitis (HTG-AP) in the USA in 2018
Outcomes	Index admission of HTG-AP	30-day readmission of HTG-AP	aOR (95% CI)	P value
^aMean difference. aOR: adjusted odds ratio; CI: confidence interval.
Inpatient mortality (%)	0.7	1.7	2.55 (1.83 - 3.57)	< 0.001
Mean length of stay (days)	4.1	5.6	1.5^a (1.2 - 1.7)	< 0.001
Mean total hospital charge ($)	36,078	56,779	18,702^a (15,136 - 22,267)	< 0.001

Table 3. Comparison of Clinical Outcomes for Index and 30-Day Readmissions of Hypertriglyceridemia-Induced Acute Pancreatitis (HTG-AP) in the USA in 2018

Outcomes

Index admission of HTG-AP

30-day readmission of HTG-AP

aOR (95% CI)

P value

^aMean difference. aOR: adjusted odds ratio; CI: confidence interval.

Inpatient mortality (%)

0.7

1.7

2.55 (1.83 - 3.57)

< 0.001

Mean length of stay (days)

4.1

5.6

1.5^a (1.2 - 1.7)

< 0.001

Mean total hospital charge ($)

36,078

56,779

18,702^a (15,136 - 22,267)

< 0.001

**Table 4.** Predictors of 30-Day Readmissions of Hypertriglyceridemia-Induced Acute Pancreatitis (HTG-AP) in the USA in 2018
Variable	aHR	95% CI	P value
aHR: adjusted hazard ratio; CI: confidence interval.
Protein energy malnutrition	1.96	1.68 - 2.28	< 0.001
Discharge against medical advice	1.80	1.44 - 2.24	< 0.001
Charlson comorbidity index score ≥ 3	1.80	1.53 - 2.11	< 0.001
Chronic kidney disease	1.29	1.11 - 1.49	0.001
Hypertension	1.12	1.01 - 1.26	0.041
Age	0.99	0.98 - 0.99	< 0.001
Obesity	0.83	0.74 - 0.93	0.001

Table 4. Predictors of 30-Day Readmissions of Hypertriglyceridemia-Induced Acute Pancreatitis (HTG-AP) in the USA in 2018

Variable

aHR

95% CI

P value

aHR: adjusted hazard ratio; CI: confidence interval.

Protein energy malnutrition

1.96

1.68 - 2.28

< 0.001

Discharge against medical advice

1.80

1.44 - 2.24

< 0.001

Charlson comorbidity index score ≥ 3

1.80

1.53 - 2.11

< 0.001

Chronic kidney disease

1.29

1.11 - 1.49

0.001

Hypertension

1.12

1.01 - 1.26

0.041

Age

0.99

0.98 - 0.99

< 0.001

Obesity

0.83

0.74 - 0.93

0.001