Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website https://www.gastrores.org

Original Article

Volume 14, Number 4, August 2021, pages 209-213

The Roles of Fibrosis Index Based on Four Factors and Aspartate Transaminase-to-Platelet Ratio Index Scoring Systems as an Alternative to Transient Elastography Liver Stiffness in Liver Fibrosis Staging in Human Immunodeficiency Virus and Hepatitis C Virus Co-Infected Patients

**Table 1.** Baseline and Clinical Characteristics of the Study Population (n = 344)
Characteristics
SD: standard deviation; TE-LS: transient elastography liver stiffness; APRI: aspartate transaminase-to-platelet ratio index; FIB-4: fibrosis index based on four factors.
Baseline characteristics
Age (average ± SD)	56.16 ± 10.46
Gender
Male	234
Female	100
Not disclosed	10
Clinical characteristics
Alanine aminotransferase (normal range 9 - 46 U/L) (median ± interquartile range)	21 ± 16.75
Aspartate aminotransferase (normal range 10 - 36 U/L) (median ± interquartile range)	23 ± 11
Platelets (normal range 150 - 450 × 10³/µL) (median ± interquartile range)	216 ± 83
TE-LS (median ± interquartile range)	5.4 ± 2.6
Stages of liver cirrhosis according to TE-LS, n/N (%)
F0-1 (< 7 kPa)	285/344 (82.8%)
F2 (7 - 8.9 kPa)	16/344 (4.7%)
F3 (9 - 11.9 kPa)	14/344 (4.1%)
F4 (≥ 12 kPa)	29/344 (8.4%)
APRI (median ± interquartile range)	0.26 ± 0.17
F0-1	0.26 ± 0.15
F2	0.25 ± 0.17
F3	0.32 ± 0.32
F4	0.54 ± 0.62
FIB-4 (median ± interquartile range)	1.31 ± 0.91
F0-1	1.27 ± 0.86
F2	1.26 ± 1.37
F3	1.67 ± 1.29
F4	2.51 ± 2.08

Table 1. Baseline and Clinical Characteristics of the Study Population (n = 344)

Characteristics

SD: standard deviation; TE-LS: transient elastography liver stiffness; APRI: aspartate transaminase-to-platelet ratio index; FIB-4: fibrosis index based on four factors.

Baseline characteristics

Age (average ± SD)

56.16 ± 10.46

Gender

Male

234

Female

100

Not disclosed

Clinical characteristics

Alanine aminotransferase (normal range 9 - 46 U/L) (median ± interquartile range)

21 ± 16.75

Aspartate aminotransferase (normal range 10 - 36 U/L) (median ± interquartile range)

23 ± 11

Platelets (normal range 150 - 450 × 10³/µL) (median ± interquartile range)

216 ± 83

TE-LS (median ± interquartile range)

5.4 ± 2.6

Stages of liver cirrhosis according to TE-LS, n/N (%)

F0-1 (< 7 kPa)

285/344 (82.8%)

F2 (7 - 8.9 kPa)

16/344 (4.7%)

F3 (9 - 11.9 kPa)

14/344 (4.1%)

F4 (≥ 12 kPa)

29/344 (8.4%)

APRI (median ± interquartile range)

0.26 ± 0.17

F0-1

0.26 ± 0.15

0.25 ± 0.17

0.32 ± 0.32

0.54 ± 0.62

FIB-4 (median ± interquartile range)

1.31 ± 0.91

F0-1

1.27 ± 0.86

1.26 ± 1.37

1.67 ± 1.29

2.51 ± 2.08

**Table 2.** APRI Cutoff < 0.5 (No Cirrhosis) and ≥ 0.5 (Significant Fibrosis)
APRI: aspartate transaminase-to-platelet ratio index; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve.
Sensitivity	35.59%
Specificity	91.23%
PPV	45.65%
NPV	87.25%
AUC	0.2218

Table 2. APRI Cutoff < 0.5 (No Cirrhosis) and ≥ 0.5 (Significant Fibrosis)

APRI: aspartate transaminase-to-platelet ratio index; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve.

Sensitivity

35.59%

Specificity

91.23%

PPV

45.65%

NPV

87.25%

AUC

0.2218

**Table 3.** FIB-4 Cutoff < 1.45 (No Cirrhosis) and ≥ 1.45 (Significant Fibrosis)
FIB-4: fibrosis index based on four factors; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve.
Sensitivity	64.41%
Specificity	62.46%
PPV	26.21%
NPV	89.45%
AUC	0.5098

Table 3. FIB-4 Cutoff < 1.45 (No Cirrhosis) and ≥ 1.45 (Significant Fibrosis)

FIB-4: fibrosis index based on four factors; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve.

Sensitivity

64.41%

Specificity

62.46%

PPV

26.21%

NPV

89.45%

AUC

0.5098

**Table 4.** FIB-4 ≥ 1.45 (Significant Fibrosis) and APRI ≥ 0.5 (Significant Fibrosis)
FIB-4: fibrosis index based on four factors; APRI: aspartate transaminase-to-platelet ratio index; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve.
Sensitivity	50.00%
Specificity	88.44%
PPV	47.73%
NPV	89.34%
AUC	0.2183

Table 4. FIB-4 ≥ 1.45 (Significant Fibrosis) and APRI ≥ 0.5 (Significant Fibrosis)

FIB-4: fibrosis index based on four factors; APRI: aspartate transaminase-to-platelet ratio index; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve.

Sensitivity

50.00%

Specificity

88.44%

PPV

47.73%

NPV

89.34%

AUC

0.2183