Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
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Case Report

Volume 13, Number 2, April 2020, pages 81-84

Reactivation of Epstein-Barr Virus Hepatitis in T/Natural Killer (NK) Cells Mimicking Liver T/NK-Cell Lymphoma


Figure 1.
Figure 1. Liver biopsy shows acute hepatitis with portal inflammation (a), lobular confluent necrosis (b, arrow heads), mild steatosis and occasional ballooning hepatocytes (b, arrow) and atypical lymphoid cells in the sinusoids (c, arrow) with phagocytosis (d, arrow) (H&E stain: a, × 100, b-d, × 400). H&E: hematoxylin-eosin.
Figure 2.
Figure 2. EBV-associated hepatitis: (a-c) immunohistochemistry showing that the atypical lymphoid cells are negative for CD20 (a, left), positive for CD3 (a, right), CD4 (b, left), rarely positive for CD8 (b, right), positive for CD56 (c); (d) EBER in situ hybridization showing that individual lymphoid cells are positive. (a-d, × 400). EBV: Epstein-Barr virus; EBER: Epstein-Barr virus encoding RNA.