Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website http://www.gastrores.org

Original Article

Volume 13, Number 2, April 2020, pages 66-72

The Relationship Between Number of Comorbidities and Age of Colorectal Cancer Diagnosis in US Male Veteran Population: A Single-Center Experience

Figure 1. Relationship between race and comorbidity and age of CRC diagnosis. CC: Caucasian; AA: African American; NTAB: non-tobacco abuse; TAB: tobacco abuse; NAAB: non-alcohol abuse; AAB: alcohol abuse; NO: non-obese; O: obese; CRC: colorectal cancer.

**Table 1.** Patient Characteristics and Mean Age of Diagnosis (N = 362)
Variable	Level	N (%)	Age at diagnosis: mean (SD)	Univariable P value for difference in age
SD: standard deviation; HTN: hypertension; CKD: chronic kidney disease; DM: diabetes mellitus; N/A: not applicable.
Race	Caucasian	290 (80.1%)	67.5 (10.6)	0.01
	African American	72 (19.9%)	63.7 (10.1)
Tobacco abuse	Yes	231 (63.8%)	65.4 (10.3)	0.001
	No	131 (36.2%)	69.2 (10.6)
Alcohol abuse	Yes	111 (30.7%)	63.6 (10.2)	< 0.001
	No	251 (69.3%)	68.2 (10.5)
HTN	Yes	264 (72.9%)	67.5 (10.4)	0.04
	No	98 (27.1%)	64.9 (10.8)
CKD	Yes	56 (15.5%)	69.6 (10.4)	0.03
	No	306 (84.5%)	66.3 (10.5)
DM I or II	Yes	147 (40.6%)	66.6 (10.0)	0.78
	No	215 (59.4%)	66.9 (11.0)
Obesity (BMI ≥ 30)	Yes	95 (26.2%)	65.4 (10.0)	0.15
	No	267 (72.9%)	67.3 (10.8)
Total count of tobacco, alcohol, obesity	0	75 (20.7%)	71.3 (9.4)	< 0.001
	1	152 (42.0%)	67.0 (11.1)
	2	120 (33.2%)	64.2 (10.0)
	3	15 (4.1%)	62.1 (7.0)
Total	N/A	362 (100%)	66.8 (10.6)	N/A

Table 1. Patient Characteristics and Mean Age of Diagnosis (N = 362)

Variable

Level

N (%)

Age at diagnosis: mean (SD)

Univariable P value for difference in age

SD: standard deviation; HTN: hypertension; CKD: chronic kidney disease; DM: diabetes mellitus; N/A: not applicable.

Race

Caucasian

290 (80.1%)

67.5 (10.6)

0.01

African American

72 (19.9%)

63.7 (10.1)

Tobacco abuse

Yes

231 (63.8%)

65.4 (10.3)

0.001

131 (36.2%)

69.2 (10.6)

Alcohol abuse

Yes

111 (30.7%)

63.6 (10.2)

< 0.001

251 (69.3%)

68.2 (10.5)

HTN

Yes

264 (72.9%)

67.5 (10.4)

0.04

98 (27.1%)

64.9 (10.8)

CKD

Yes

56 (15.5%)

69.6 (10.4)

0.03

306 (84.5%)

66.3 (10.5)

DM I or II

Yes

147 (40.6%)

66.6 (10.0)

0.78

215 (59.4%)

66.9 (11.0)

Obesity (BMI ≥ 30)

Yes

95 (26.2%)

65.4 (10.0)

0.15

267 (72.9%)

67.3 (10.8)

Total count of tobacco, alcohol, obesity

75 (20.7%)

71.3 (9.4)

< 0.001

152 (42.0%)

67.0 (11.1)

120 (33.2%)

64.2 (10.0)

15 (4.1%)

62.1 (7.0)

Total

N/A

362 (100%)

66.8 (10.6)

N/A

**Table 2.** Multivariable Linear Regression Model for Age at Diagnosis
Variable	Level	Model coefficient^a (SE)	P value
^aThe adjusted mean difference in age at diagnosis (a negative coefficient indicates a lower age at diagnosis). SE: standard error of estimated coefficient; HTN: hypertension; CKD: chronic kidney disease; DM: diabetes mellitus.
Race	African American	-3.8 (1.3)	0.01
	White	Reference	Reference
Total count of tobacco, alcohol, obesity	0	Reference	Reference
	1	-4.1 (1.4)	0.004
	2	-6.8 (1.5)	< 0.001
	3	-8.9 (2.9)	0.002
HTN	Present vs. not	3.1 (1.2)	0.01
CKD	Present vs. not	2.7 (1.6)	0.08
DM I or II	Present vs. not	-1.5 (1.1)	0.20

Table 2. Multivariable Linear Regression Model for Age at Diagnosis

Variable

Level

Model coefficient^a (SE)

P value

^aThe adjusted mean difference in age at diagnosis (a negative coefficient indicates a lower age at diagnosis). SE: standard error of estimated coefficient; HTN: hypertension; CKD: chronic kidney disease; DM: diabetes mellitus.

Race

African American

-3.8 (1.3)

0.01

White

Reference

Total count of tobacco, alcohol, obesity

Reference

-4.1 (1.4)

0.004

-6.8 (1.5)

< 0.001

-8.9 (2.9)

0.002

HTN

Present vs. not

3.1 (1.2)

0.01

CKD

Present vs. not

2.7 (1.6)

0.08

DM I or II

Present vs. not

-1.5 (1.1)

0.20

**Table 3.** Breakdown of the Tobacco, Alcohol, and Obesity Comorbidity Combinations
Total count	Tobacco	Alcohol	Obesity	N (%)
3	Yes	Yes	Yes	15 (4.1%)
2	Yes	Yes	No	74 (20.4%)
	Yes	No	Yes	43 (11.9%)
	No	Yes	Yes	3 (0.8%)
1	Yes	No	No	99 (27.3%)
	No	Yes	No	19 (5.2%)
	No	No	Yes	34 (9.4%)
0	No	No	No	75 (20.7%)

Table 3. Breakdown of the Tobacco, Alcohol, and Obesity Comorbidity Combinations

Total count

Tobacco

Alcohol

Obesity

N (%)

Yes

15 (4.1%)

Yes

74 (20.4%)

Yes

43 (11.9%)

Yes

3 (0.8%)

Yes

99 (27.3%)

Yes

19 (5.2%)

Yes

34 (9.4%)

75 (20.7%)