Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 13, Number 3, June 2020, pages 101-106

Use of Vitamin D With Anti-Tumor Necrosis Factor Therapy for Crohn’s Disease

Figures

Figure 1.
Figure 1. Study design of vitamin D dosage and groups at the intervention period of 8 weeks and the observation period of 52 weeks.
Figure 2.
Figure 2. Vitamin D levels in groups G1, G2, and G3, before and after supplementation.
Figure 3.
Figure 3. CRP levels in groups G1, G2, and G3, before and after vitamin D supplementation. CRP: C-reactive protein.
Figure 4.
Figure 4. FC levels in groups G1, G2, and G3, before and after vitamin D supplementation. FC: fecal calprotectin.
Figure 5.
Figure 5. Patients with CD activity in the observation period, during 52 weeks follow-up with vitamin D > 30 or < 30. **CD activity: CDAI > 150, FC > 200 and CT scan. CD: Crohn’s disease; FC: fecal calprotectin; CDAI: Crohn’s disease activity index; CT: computerized tomography.
Figure 6.
Figure 6. Levels of vitamin D in CD patients after an observation period of 52 weeks that presented flare or disease remission. CD: Crohn’s disease.

Tables

Table 1. Demographic Data of Patients (N = 30)
 
VariablesResults
Age (mean) (years)37
Gender
  Male15
  Female15
Age of diagnosis (Montreal classification)
  A1 (below 16 years)2
  A2 (between 17 and 40 years)23
  A3 (above 40 years)5
Location
  L1 (ileal)11
  L2 (colonic)4
  L3 (ileocolonic)15
Behavior
  B1 (non-stricturing, non-penetrating)8
  B2 (stricturing)10
  B3 (penetrating)7
  B2 + B35
Perianal disease5
Duration of disease
  < 5 years16
  > 5 years14
Basal vitamin D19.3

 

Table 2. Patients Data Before Starting Vitamin D Supplement
 
GroupsAge (years)Sex (n)Duration of disease (years) (n)Location of disease (n)CRPFCVitamin D levels
M: male; F: female; CRP: C-reactive protein; FC: fecal calprotectin; L1: ileal; L2: colonic; L3: ileocolonic.
G141M (2)> 5 (6)L1 (3)8.11,10119.5
F (8)< 5 (4)L2 (2)
L3 (5)
G237M (8)> 5 (5)L1 (4)5.876719.1
F (2)< 5 (5)L2 (1)
L3 (5)
G333M (5)> 5 (5)L1 (4)5.21,01419.5
F (5)< 5 (5)L2 (1)
L3 (5)