Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 12, Number 4, August 2019, pages 185-190

Pancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation

Figures

Figure 1.
Figure 1. Luminal staining for CEA, assessed by immunohistochemistry and graded as 0 to 3+. (a) Luminal CEA: 1+ (× 200). (b) Luminal CEA: 2+ (× 200). (c) Luminal CEA: 3+ (× 200).
Figure 2.
Figure 2. (a) Box and whisker plot of pre-operative IPMN cyst fluid CEA level (ng/mL) vs. IPMN subtypes. (b) Box and whisker plot of pre-operative IPMN cyst fluid CEA level (ng/mL) vs. CEA luminal staining assessed by immunohistochemistry of resected IPMNs.
Figure 3.
Figure 3. Pre-operative pancreatic cyst fluid CEA level and corresponding tumor size (cm).
Figure 4.
Figure 4. Receiver operator characteristic (ROC) curve of pre-operative CEA cyst fluid level for invasive carcinoma.

Tables

Table 1. Pearson Correlation Between Pre-Operative Pancreatic Cyst Fluid CEA Level and CEA Immunohistochemical Staining Intensity
 
CEA level
*Correlation is significant at the 0.05 level (two-tailed).
CEA-P-IPMN lumenalPearson correlation0.611
Sig. (two-tailed)0.000*
N40
CEA-P-IPMN cytoplasmPearson correlation0.099
Sig. (two-tailed)0.541
N40
CEA-P-IPMN secretionPearson correlation0.028
Sig. (two-tailed)0.861
N40

 

Table 2. Pearson Correlation Between Pre-Operative Pancreatic Cyst Fluid CEA Level and MUC1, MUC2, MUC5, MUC6 Immunohistochemical Staining Intensity
 
CEA level
MUC1-IPMN lumenalPearson correlation-0.137
Sig. (two-tailed)0.477
N29
MUC1-IPMN cytoplasmPearson correlation-0.103
Sig. (two-tailed)0.594
N29
MUC1-IPMN secretionPearson correlation-0.076
Sig. (two-tailed)0.696
N29
MUC2-pancreasePearson correlation-0.082
Sig. (two-tailed)0.616
N40
MUC2-IPMN cytoplasmPearson correlation0.259
Sig. (two-tailed)0.107
N40
MUC5-IPMN lumenalPearson correlation0.000
Sig. (two-tailed)0.998
N40
MUC5-IPMN cytoplasmPearson correlation-0.039
Sig. (two-tailed)0.812
N40
MUC5-IPMN secretionPearson correlation0.038
Sig. (two-tailed)0.818
N40
MUC6-IPMN lumenalPearson correlation-0.126
Sig. (two-tailed)0.507
N30
MUC6-IPMN cytoplasmPearson correlation0.259
Sig. (two-tailed)0.167
N30
MUC6-IPMN secretionPearson correlation-0.174
Sig. (two-tailed)0.357
N30
MUC6-pancreasePearson correlation-0.105
Sig. (two-tailed)0.582
N30

 

Table 3. Pearson Correlation Between Pre-Operative Pancreatic Cyst Fluid CEA Level and Tumor Size, Presence of Invasive Carcinoma and CDX2 Nuclear Staining Within IPMNs
 
CEA level
*Correlation is significant at the 0.05 level (two-tailed).
Tumor size (cm)Pearson correlation-0.015
Sig. (two-tailed)0.930
N38
CarcinomaPearson correlation0.070
Sig. (two-tailed)0.668
N40
CDX2-nuclearPearson correlation0.343*
Sig. (two-tailed)0.030
N40