Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website http://www.gastrores.org

Original Article

Volume 11, Number 6, December 2018, pages 397-403


Long-Term Safety and Efficacy of Fecal Microbiota Transplantation in the Treatment of Clostridium difficile Infection in Patients With and Without Inflammatory Bowel Disease: A Tertiary Care Center’s Experience

Figure

Figure 1.
Figure 1. Flow diagram depicting all patients undergone FMT and their outcomes.

Tables

Table 1. Characteristics of Patients With and Without IBD
 
IBD (n = 21)Non-IBD (n = 57)
*P < 0.05. FMT: fecal microbiota transplant; CLN: colonoscopy; TI: terminal ileum; G/J: gastrostomy and/or jejunostomy.
Age in years, mean (SD)47.6 (20.7)*61.2 (19.3)*
Gender n (%)
  Female9 (42.9)*45 (79.0)*
  Male12 (57.1)*12 (21.1)*
FMT settings n (%)
  Inpatient4 (19.1)6 (10.5)
  Outpatient17 (81.0)51 (89.5)
Abdominal pain n (%)15 (71.4)*26 (45.6)*
Severity of diarrhea n (%)
  Mild0 (0.0)7 (12.3)
  Moderate15 (71.4)38 (66.7)
  Severe6 (28.6)12 (21.1)
Source of stool n (%)
  First degree relative7 (33.3)21 (36.8)
  OpenBiome13 (61.9)34 (59.7)
  Friend1 (4.8)1 (1.8)
  Med student0 (0.0)1 (1.8)
Method of delivery n (%)
  CLN to TI18 (85.7)44 (77.2)
  CLN to cecum1 (4.8)5 (8.8)
  Throughout colon0 (0.0)1 (1.8)
  Flex sigmoidoscopy1 (4.8)2 (3.5)
  Enema0 (0.0)1 (1.8)
  G/J tube0 (0.0)2 (3.5)
  Enteroscopy to jejunum0 (0.0)1 (1.8)
Antibiotics used n (%)
  PO metronidazole15 (71.4)40 (70.2)
  PO vancomycin21 (100.0)52 (91.2)
  IV vancomycin3 (14.3)5 (8.8)
  Fidaxomycin7 (33.3)15 (26.3)

 

Table 2. Comparison of Patients With IBD vs. Non-IBD
 
IBD (n = 21)Non-IBD (n = 57)Total
Primary cure15 (71.4%)45 (78.9%)60 (76.9%)
Secondary cure21 (100%)57 (100%)78 (100%)
Early recurrence2 (9.5%)6 (10.5%)8 (10.25%)
Late recurrence4 (19.0%)6 (10.5%)10 (12.8%)
Repeat FMT4 (57.1%)3 (42.8%)7 (8.9%)

 

Table 3. Complications After FMT in IBD Patients by Recurrence of CDI
 
Recurrence (n = 6)No recurrence (n = 15)All IBD patients (n = 21)
Colectomy1 (16.7)1 (6.7)2 ( 9.5)
Hospitalizations for IBD flare1 (16.7)4 (26.7)5 (23.8)
Ileal resection1 (16.7)0 (0.0)1 (4.7)
None3 (50.0)10 (66.7)13 (61.9)